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P49354 Proteins with PFTA Repeats

Uniprot ID: P49354	Protein name : Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Gene : FNTA
Protein Families : Protein prenyltransferase subunit alpha family	Squence Length : 379

Sequence	>P49354 380 MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDSPSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTENDSPTNVQQ
Repeat regions	REPEAT 112 146 PFTA 1 REPEAT 147 180 PFTA 2 REPEAT 181 215 PFTA 3 REPEAT 216 249 PFTA 4 REPEAT 255 289 PFTA 5
Sequence region of repeats	112- 146 ERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDL 147- 180 HEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDP 181- 215 SQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWD 216- 249 NELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYN 255- 289 EREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSK
Function	Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation
Mutation	164 164 K->N: Reduced activity 199 199 N->K: Reduced catalytic efficiency