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P57078 Proteins with ANK Repeats

Uniprot ID: P57078	Protein name : Receptor-interacting serine/threonine-protein kinase 4	Gene : RIPK4 ANKRD3 DIK
Protein Families : "Protein kinase superfamily, TKL Ser/Thr protein kinase family"	Squence Length : 832

Sequence	>P57078 833 MEGDGGTPWALALLRTFDAGEFTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGICREPVGLVMEYMETGSLEKLLASEPLPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQGNGLNGELIRQVLAALLPVTGRWRSPGEGFRLESEVIIRVTCPLSSPQEITSETEDLCEKPDDEVKETAHDLDVKSPPEPRSEVVPARLKRASAPTFDNDYSLSELLSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGPAATLLRRSKT
Repeat regions	REPEAT 485 514 ANK 1 REPEAT 518 547 ANK 2 REPEAT 551 580 ANK 3 REPEAT 584 613 ANK 4 REPEAT 617 647 ANK 5 REPEAT 651 680 ANK 6 REPEAT 684 713 ANK 7 REPEAT 717 746 ANK 8 REPEAT 750 780 ANK 9 REPEAT 782 811 ANK 10
Sequence region of repeats	485- 514 ASLLHLAVEAGQEECAKWLLLNNANPNLSN 518- 547 STPLHMAVERRVRGVVELLLARKISVNAKD 551- 580 WTALHFAAQNGDESSTRLLLEKNASVNEVD 584- 613 RTPMHVACQHGQENIVRILLRRGVDVSLQG 617- 647 WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQT 651- 680 RTPLHLAAQRGHYRVARILIDLCSDVNVCS 684- 713 QTPLHVAAETGHTSTARLLLHRGAGKEAMT 717- 746 YTALHLAARNGHLATVKLLVEEKADVLARG 750- 780 QTALHLAAAHGHSEVVEELVSADVIDLFDEQ 782- 811 LSALHLAAQGRHAQTVETLLRHGAHINLQS
Domains	DOMAIN 22 286 Protein kinase
Function	Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation
Active Site	ACT_SITE 143 143 Proton acceptor
Binding Site	BINDING 51 51 ATP
Nucleotide Binding	NP_BIND 28 36 ATP
Disease	"DISEASE: Popliteal pterygium syndrome, lethal type (PPS-L) [MIM:263650]: An autosomal recessive disorder characterized by multiple popliteal pterygia leading to severe arthrogryposis, ankyloblepharon filiforme adnatum, filiform bands between the jaws, synostosis of the carpal/tarsal and phalangeal bones in the hands and feet, digital hypoplasia/aplasia, complete soft-tissue syndactyly, lack of nails, lack of scalp hair, eyebrows and eyelashes, blepharophimosis, cleft lip and/or palate, and hypoplastic external genitalia Early lethality is common, although survival into childhood and beyond has been reported Note=The disease is caused by mutations affecting the gene represented in this entry"