BACK HOME

P59046 Proteins with LRR Repeats

Uniprot ID: P59046	Protein name : "NACHT, LRR and PYD domains-containing protein 12 "	Gene : NLRP12 NALP12 PYPAF7 RNO
Protein Families : NLRP family	Squence Length : 1061

Sequence	>P59046 1062 MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
Repeat regions	REPEAT 828 848 LRR 1 REPEAT 857 878 LRR 2 REPEAT 885 906 LRR 3 REPEAT 914 935 LRR 4 REPEAT 942 962 LRR 5 REPEAT 971 992 LRR 6 REPEAT 999 1020 LRR 7 REPEAT 1028 1049 LRR 8
Sequence region of repeats	828- 848 VELDLTGNALEDLGLRLLCQG 857- 878 RTLWLKICRLTAAACDELASTL 885- 906 RELDLSLNELGDLGVLLLCEGL 914- 935 QTLRLGICRLGSAACEGLSVVL 942- 962 RELDLSFNDLGDWGLWLLAEG 971- 992 QKLWLDSCGLTAKACENLYFTL 999- 1020 TDLYLTNNALGDTGVRLLCKRL 1028- 1049 RVLWLFGMDLNKMTHSRLAALR
Domains	DOMAIN 1 95 Pyrin. DOMAIN 211 528 NACHT
Function	May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK
Nucleotide Binding	NP_BIND 217 224 ATP
Disease	"DISEASE: Familial cold autoinflammatory syndrome 2 (FCAS2) [MIM:611762]: A rare autosomal dominant systemic inflammatory disease characterized by recurrent episodes of maculopapular rash associated with arthralgias, myalgias, fever and chills, swelling of the extremities, and conjunctivitis after generalized exposure to cold Note=The disease is caused by mutations affecting the gene represented in this entry"