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Q08752 Proteins with TPR Repeats

Uniprot ID: Q08752	Protein name : Peptidyl-prolyl cis-trans isomerase D	Gene : PPID CYP40 CYPD
Protein Families : "Cyclophilin-type PPIase family, PPIase D subfamily"	Squence Length : 370

Sequence	>Q08752 371 MSHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGHTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGRNTNGSQFFITTVPTPHLDGKHVVFGQVIKGIGVARILENVEVKGEKPAKLCVIAECGELKEGDDGGIFPKDGSGDSHPDFPEDADIDLKDVDKILLITEDLKNIGNTFFKSQNWEMAIKKYAEVLRYVDSSKAVIETADRAKLQPIALSCVLNIGACKLKMSNWQGAIDSCLEALELDPSNTKALYRRAQGWQGLKEYDQALADLKKAQGIAPEDKAIQAELLKVKQKIKAQKDKEKAVYAKMFA
Repeat regions	REPEAT 223 256 TPR 1 REPEAT 273 306 TPR 2 REPEAT 307 340 TPR 3
Sequence region of repeats	223- 256 DLKNIGNTFFKSQNWEMAIKKYAEVLRYVDSSKA 273- 306 CVLNIGACKLKMSNWQGAIDSCLEALELDPSNTK 307- 340 ALYRRAQGWQGLKEYDQALADLKKAQGIAPEDKA
Domains	DOMAIN 19 183 PPIase cyclophilin-type
Function	"PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines.; (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release"
Mutation	227 227 K->A: Abolishes interaction with HSP90AB1 and impairs interaction with HSPA8 231 231 N->A: Abolishes interaction with HSP90AB1 and impairs interaction with HSPA8 234 234 F->A: Impairs interaction with HSP90AB1 and HSPA8 274 274 S->L: Impairs interaction with HSP90AB1 and HSPA8 278 278 N->A: Abolishes interaction with HSP90AB1 284 284 L->A: Impairs interaction with HSP90AB1 and HSPA8 285 285 K->A: Impairs interaction with HSP90AB1 and HSPA8 308 308 K->A: Abolishes interaction with HSP90AB1 and impairs interaction with HSPA8 312 312 R->A: Abolishes interaction with HSP90AB1 and impairs interaction with HSPA8 329 329 D->A: Impairs interaction with HSP90AB1