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Q13641 Proteins with LRR Repeats
Uniprot ID: Q13641
Protein name : Trophoblast glycoprotein
Gene : TPBG 5T4
Protein Families :
Squence Length : 420
Sequence
>Q13641 421 MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLGIVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV
Repeat regions
REPEAT 92 113 LRR 1 REPEAT 116 139 LRR 2 REPEAT 141 163 LRR 3 REPEAT 172 204 LRR 4 REPEAT 209 232 LRR 5 REPEAT 233 255 LRR 6 REPEAT 256 275 LRR 7
Sequence region of repeats
92- 113 RNLFLTGNQLAVLPAGAFARRP 116- 139 AELAALNLSGSRLDEVRAGAFEHL 141- 163 SLRQLDLSHNPLADLSPFAFSGS 172- 204 PLVELILNHIVPPEDERQNRSFEGMVVAALLAG 209- 232 GLRRLELASNHFLYLPRDVLAQLP 233- 255 SLRHLDLSNNSLVSLTYVSFRNL 256- 275 THLESLHLEDNALKVLHNGT
Domains
DOMAIN 53 91 LRRNT. DOMAIN 283 346 LRRCT
Function
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization
Mutation
76 76 K->A: Strongly reduces Wnt inhibitory function 97 97 F->T: Strongly reduces Wnt inhibitory function 124 124 N->Q: Impaired trafficking to the cell surface 214 214 R->E: Impaired trafficking to the cell surface 325 325 Y->A: Reduces Wnt inhibitory function