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Q14112 Proteins with LDL-receptor Repeats
Uniprot ID: Q14112
Protein name : Nidogen-2
Gene : NID2
Protein Families :
Squence Length : 1375
Sequence
>Q14112 1376 MEGDRVAGRPVLSSLPVLLLLPLLMLRAAALHPDELFPHGESWGDQLLQEGDDESSAVVKLANPLHFYEARFSNLYVGTNGIISTQDFPRETQYVDYDFPTDFPAIAPFLADIDTSHGRGRVLYREDTSPAVLGLAARYVRAGFPRSARFTPTHAFLATWEQVGAYEEVKRGALPSGELNTFQAVLASDGSDSYALFLYPANGLQFLGTRPKESYNVQLQLPARVGFCRGEADDLKSEGPYFSLTSTEQSVKNLYQLSNLGIPGVWAFHIGSTSPLDNVRPAAVGDLSAAHSSVPLGRSFSHATALESDYNEDNLDYYDVNEEEAEYLPGEPEEALNGHSSIDVSFQSKVDTKPLEESSTLDPHTKEGTSLGEVGGPDLKGQVEPWDERETRSPAPPEVDRDSLAPSWETPPPYPENGSIQPYPDGGPVPSEMDVPPAHPEEEIVLRSYPASGHTTPLSRGTYEVGLEDNIGSNTEVFTYNAANKETCEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHCLPEGAPHRVNGKVSGHLHVGHTPVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPGSENGFSLAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFTAHISPYKELYHYSDSTVTSTSSRDYSLTFGAINQTWSYRIHQNITYQVCRHAPRHPSFPTTQQLNVDRVFALYNDEERVLRFAVTNQIGPVKEDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPGSTPPHCGPSPEPTQRPPTICERWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGTTPACIPTVAPPMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYPYCPTGRK
Repeat regions
REPEAT 1154 1197 LDL-receptor class B 1 REPEAT 1198 1240 LDL-receptor class B 2 REPEAT 1241 1285 LDL-receptor class B 3 REPEAT 1286 1327 LDL-receptor class B 4 REPEAT 1329 1373 LDL-receptor class B 5
Sequence region of repeats
1154- 1197 VYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRT 1198- 1240 MYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGN 1241- 1285 LYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKL 1286- 1327 LCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFY 1329- 1373 TDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYPYCPTGRK
Domains
DOMAIN 108 273 NIDO. DOMAIN 484 524 EGF-like 1. DOMAIN 528 758 Nidogen G2 beta-barrel. DOMAIN 759 800 EGF-like 2. DOMAIN 801 843 EGF-like 3. calcium-binding. DOMAIN 848 891 EGF-like 4. DOMAIN 892 930 EGF-like 5. calcium-binding. DOMAIN 937 1005 Thyroglobulin type-1 1. DOMAIN 1016 1084 Thyroglobulin type-1 2
Function
"Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions"