BACK HOME

Q59H18 Proteins with ANK Repeats

Uniprot ID: Q59H18	Protein name : Serine/threonine-protein kinase TNNI3K	Gene : TNNI3K CARK
Protein Families : "Protein kinase superfamily, TKL Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily"	Squence Length : 835

Sequence	>Q59H18 836 MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS
Repeat regions	REPEAT 66 96 ANK 1 REPEAT 100 129 ANK 2 REPEAT 133 162 ANK 3 REPEAT 166 195 ANK 4 REPEAT 199 228 ANK 5 REPEAT 234 263 ANK 6 REPEAT 269 298 ANK 7 REPEAT 304 335 ANK 8 REPEAT 339 368 ANK 9 REPEAT 381 410 ANK 10
Sequence region of repeats	66- 96 LSLLHLCCICGGKKSHIRTLMLKGLRPSRLT 100- 129 FTALHLAVYKDNAELITSLLHSGADIQQVG 133- 162 LTALHIATIAGHLEAADVLLQHGANVNIQD 166- 195 FTPLHIAAYYGHEQVTRLLLKFGADVNVSG 199- 228 DRPLHLASAKGFLNIAKLLMEEGSKADVNA 234- 263 HVPLHFCSRFGHHDIVKYLLQSDLEVQPHV 269- 298 DTPLHLACYNGKFEVAKEIIQISGTESLTK 304- 335 ETAFHSACTYGKSIDLVKFLLDQNVININHQG 339- 368 HTGLHSACYHGHIRLVQFLLDNGADMNLVA 381- 410 QTCLMWAYEKGHDAIVTLLKHYKRPQDELP
Domains	DOMAIN 463 723 Protein kinase
Function	May play a role in cardiac physiology
Active Site	ACT_SITE 588 588 Proton acceptor
Binding Site	BINDING 490 490 ATP
Nucleotide Binding	NP_BIND 469 477 ATP
Mutation	490 490 K->R: Loss of autophosphorylation activity
Disease	DISEASE: Cardiac conduction disease with or without dilated cardiomyopathy (CCDD) [MIM:616117]: A cardiac disorder characterized by atrial tachyarrhythmia and conduction system disease Some patients have dilated cardiomyopathy Note=The disease is caused by mutations affecting the gene represented in this entry