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Q5T2S8 Proteins with ARM Repeats
Uniprot ID: Q5T2S8
Protein name : Armadillo repeat-containing protein 4
Gene : ARMC4
Protein Families :
Squence Length : 1044
Sequence
>Q5T2S8 1045 MGVALRKLTQWTAAGHGTGILEITPLNEAILKEIIVFVESFIYKHPQEAKFVFVEPLEWNTSLAPSAFESGYVVSETTVKSEEVDKNGQPLLFLSVPQIKIRSFGQLSRLLLIAKTGKLKEAQACVEANRDPIVKILGSDYNTMKENSIALNILGKITRDDDPESEIKMKIAMLLKQLDLHLLNHSLKHISLEISLSPMTVKKDIELLKRFSGKGNQTVLESIEYTSDYEFSNGCRAPPWRQIRGEICYVLVKPHDGETLCITCSAGGVFLNGGKTDDEGDVNYERKGSIYKNLVTFLREKSPKFSENMSKLGISFSEDQQKEKDQLGKAPKKEEAAALRKDISGSDKRSLEKNQINFWRNQMTKRWEPSLNWKTTVNYKGKGSAKEIQEDKHTGKLEKPRPSVSHGRAQLLRKSAEKIEETVSDSSSESEEDEEPPDHRQEASADLPSEYWQIQKLVKYLKGGNQTATVIALCSMRDFSLAQETCQLAIRDVGGLEVLINLLETDEVKCKIGSLKILKEISHNPQIRQNIVDLGGLPIMVNILDSPHKSLKCLAAETIANVAKFKRARRVVRQHGGITKLVALLDCAHDSTKPAQSSLYEARDVEVARCGALALWSCSKSHTNKEAIRKAGGIPLLARLLKTSHENMLIPVVGTLQECASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAEDKETRDLVRLHGGLKPLASLLNNTDNKERLAAVTGAIWKCSISKENVTKFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQERENRVIVRKCGGIQPLVNLLVGINQALLVNVTKAVGACAVEPESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAITNIAKDQENLAVITDHGVVPLLSKLANTNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDADNCITMHENGAVKLLLDMVGSPDQDLQEAAAGCISNIRRLALATEKARYT
Repeat regions
REPEAT 484 523 ARM 1 REPEAT 525 564 ARM 2 REPEAT 622 661 ARM 3 REPEAT 663 702 ARM 4 REPEAT 746 785 ARM 5 REPEAT 828 867 ARM 6 REPEAT 871 910 ARM 7 REPEAT 912 951 ARM 8 REPEAT 953 992 ARM 9 REPEAT 994 1033 ARM 10
Sequence region of repeats
484- 523 CQLAIRDVGGLEVLINLLETDEVKCKIGSLKILKEISHNP 525- 564 IRQNIVDLGGLPIMVNILDSPHKSLKCLAAETIANVAKFK 622- 661 NKEAIRKAGGIPLLARLLKTSHENMLIPVVGTLQECASEE 663- 702 YRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAEDK 746- 785 NVTKFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQER 828- 867 SMMIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNA 871- 910 GEMVRSFVGGLELIVNLLKSDNKEVLASVCAAITNIAKDQ 912- 951 NLAVITDHGVVPLLSKLANTNNNKLRHHLAEAISRCCMWG 953- 992 NRVAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDA 994- 1033 NCITMHENGAVKLLLDMVGSPDQDLQEAAAGCISNIRRLA
Function
Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly
Disease
"DISEASE: Ciliary dyskinesia, primary, 23 (CILD23) [MIM:615451]: A disorder characterized by abnormalities of motile cilia Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome Note=The disease is caused by mutations affecting the gene represented in this entry Contrary to the wild-type protein, disease-causing variant Trp-927 is unable to rescue the phenotype (randomization of heart looping) of the morpholino knockdown of the orthologous protein in zebrafish (PubMed:23849778)"