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Q5T6F0 Proteins with WD Repeats

Uniprot ID: Q5T6F0	Protein name : DDB1- and CUL4-associated factor 12	Gene : DCAF12 KIAA1892 TCC52 WDR40A
Protein Families : WD repeat DCAF12 family	Squence Length : 453

Sequence	>Q5T6F0 454 MARKVVSRKRKAPASPGAGSDAQGPQFGWDHSLHKRKRLPPVKRSLVYYLKNREVRLQNETSYSRVLHGYAAQQLPSLLKEREFHLGTLNKVFASQWLNHRQVVCGTKCNTLFVVDVQTSQITKIPILKDREPGGVTQQGCGIHAIELNPSRTLLATGGDNPNSLAIYRLPTLDPVCVGDDGHKDWIFSIAWISDTMAVSGSRDGSMGLWEVTDDVLTKSDARHNVSRVPVYAHITHKALKDIPKEDTNPDNCKVRALAFNNKNKELGAVSLDGYFHLWKAENTLSKLLSTKLPYCRENVCLAYGSEWSVYAVGSQAHVSFLDPRQPSYNVKSVCSRERGSGIRSVSFYEHIITVGTGQGSLLFYDIRAQRFLEERLSACYGSKPRLAGENLKLTTGKGWLNHDETWRNYFSDIDFFPNAVYTHCYDSSGTKLFVAGGPLPSGLHGNYAGLWS
Repeat regions	REPEAT 81 122 WD 1 REPEAT 123 175 WD 2 REPEAT 176 242 WD 3 REPEAT 243 286 WD 4 REPEAT 287 331 WD 5 REPEAT 332 366 WD 6
Sequence region of repeats	81- 122 EFHLGTLNKVFASQWLNHRQVVCGTKCNTLFVVDVQTSQITK 123- 175 IPILKDREPGGVTQQGCGIHAIELNPSRTLLATGGDNPNSLAIYRLPTLDPVC 176- 242 VGDDGHKDWIFSIAWISDTMAVSGSRDGSMGLWEVTDDVLTKSDARHNVSRVPVYAHITHKALKDIP 243- 286 KEDTNPDNCKVRALAFNNKNKELGAVSLDGYFHLWKAENTLSKL 287- 331 LSTKLPYCRENVCLAYGSEWSVYAVGSQAHVSFLDPRQPSYNVKS 332- 366 VCSRERGSGIRSVSFYEHIITVGTGQGSLLFYDIR
Function	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex
Mutation	368 368 R->A: Reduces association with DDB1