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Q6P1M3 Proteins with WD Repeats
Uniprot ID: Q6P1M3
Protein name : Lethal
Gene : LLGL2
Protein Families : WD repeat L(2)GL family
Squence Length : 1020
Sequence
>Q6P1M3 1021 MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDPNENFSAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEAAEQAVEQVEADLLQDQEGYRWKGHERLAARSGPVRFEPGFQPFVLVQCQPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRMRRSRVSSRKRHPAGPPGEAQEGSAKAERPGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLKDSSRHCPSLWAGTNGGTIYAFSLRVPPAERRMDEPVRAEQAKEIQLMHRAPVVGILVLDGHSVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSAKLKLKLTALEGSRVRRVSVAHFGSRRAEDYGEHHLAVLTNLGDIQVVSLPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYLISPSEFERFSLSTKWLVEPRCLVDSAETKNHRPGNGAGPKKAPSRARNSGTQSDGEEKQPGLVMERALLSDERVLKEIQSTLEGDRGSGNWRSHRAAVGCSLSNGGAE
Repeat regions
REPEAT 36 69 WD 1 REPEAT 76 117 WD 2 REPEAT 132 169 WD 3 REPEAT 193 227 WD 4 REPEAT 233 268 WD 5 REPEAT 282 324 WD 6 REPEAT 332 366 WD 7 REPEAT 388 464 WD 8 REPEAT 508 583 WD 9 REPEAT 592 653 WD 10 REPEAT 713 769 WD 11 REPEAT 778 830 WD 12 REPEAT 835 888 WD 13 REPEAT 902 925 WD 14
Sequence region of repeats
36- 69 LGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQ 76- 117 QIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTL 132- 169 VVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISS 193- 227 QEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLS 233- 268 NIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLR 282- 324 TRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAF 332- 366 GFTVLTEADPAATFDDPYALVVLAEEELVVIDLQT 388- 464 SHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTV 508- 583 IFLCKYSGYLAVAGTAGQVLVLELNDEAAEQAVEQVEADLLQDQEGYRWKGHERLAARSGPVRFEPGFQPFVLVQC 592- 653 LALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFR 713- 769 TLYFADTYLKDSSRHCPSLWAGTNGGTIYAFSLRVPPAERRMDEPVRAEQAKEIQLM 778- 830 LVLDGHSVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSAKLK 835- 888 ALEGSRVRRVSVAHFGSRRAEDYGEHHLAVLTNLGDIQVVSLPLLKPQVRYSCI 902- 925 TKYGQGFYLISPSEFERFSLSTKW
Function
"Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity"
Mutation
641 641 S->A: No effect on phosphorylation 645 645 S->A: Decrease of phosphorylation 649 649 S->A: Decrease of phosphorylation 653 653 S->A: Loss of phosphorylation 660 660 S->A: Decrease of phosphorylation 663 663 S->A: No effect on phosphorylation