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Q8IUH5 Proteins with ANK Repeats

Uniprot ID: Q8IUH5	Protein name : Palmitoyltransferase ZDHHC17	Gene : ZDHHC17 HIP14 HIP3 HYPH KIAA0946 HSPC294
Protein Families : "DHHC palmitoyltransferase family, AKR/ZDHHC17 subfamily"	Squence Length : 632

Sequence	>Q8IUH5 633 MQREEGFNTKMADGPDEYDTEAGCVPLLHPEEIKPQSHYNHGYGEPLGRKTHIDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKEFRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMYQISCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYDQISGSGYQLV
Repeat regions	REPEAT 51 86 ANK 1 REPEAT 89 118 ANK 2 REPEAT 123 152 ANK 3 REPEAT 156 185 ANK 4 REPEAT 189 219 ANK 5 REPEAT 224 253 ANK 6 REPEAT 257 286 ANK 7
Sequence region of repeats	51- 86 IDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDK 89- 118 VTLLHWAAINNRIDLVKYYISKGAIVDQLG 123- 152 STPLHWATRQGHLSMVVQLMKYGADPSLID 156- 185 CSCIHLAAQFGHTSIVAYLIAKGQDVDMMD 189- 219 MTPLMWAAYRTHSVDPTRLLLTFNVSVNLGD 224- 253 NTALHWAVLAGNTTVISLLLEAGANVDAQN 257- 286 ESALDLAKQRKNVWMINHLQEARQAKGYDN
Domains	DOMAIN 437 487 DHHC
Function	"Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145). Palmitoylates MPP1 in erythrocytes (PubMed:22496366). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg(2+) transport (PubMed:18794299)"
Active Site	ACT_SITE 467 467 S-palmitoyl cysteine intermediate
Mutation	67 67 Y->A: Decreased binding affinity for SNAP25 89 89 E->A: No effect on SNAP25 binding 100 100 N->A: Abolishes SNAP25 binding 122 122 D->A: Mildly decreased binding affinity for SNAP25 130 130 W->A: Abolishes SNAP25 and HTT binding 467 467 C->S: Abolishes palmitoyltransferase activity