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Q8NER1 Proteins with ANK Repeats

Uniprot ID: Q8NER1	Protein name : Transient receptor potential cation channel subfamily V member 1	Gene : TRPV1 VR1
Protein Families : "Transient receptor (TC 1.A.4) family, TrpV subfamily, TRPV1 sub-subfamily"	Squence Length : 839

Sequence	>Q8NER1 840 MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFPVDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK
Repeat regions	REPEAT 111 153 ANK 1 REPEAT 154 200 ANK 2 REPEAT 201 247 ANK 3 REPEAT 248 283 ANK 4 REPEAT 284 332 ANK 5 REPEAT 333 359 ANK 6
Sequence region of repeats	111- 153 YDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETG 154- 200 KTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKG 201- 247 QTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFG 248- 283 ELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVG 284- 332 NTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKG 333- 359 MTPLALAAGTGKIGVLAYILQREIQEP
Function	"Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis"
Motifs	MOTIF 644 647 Selectivity filter
Binding Site	BINDING 116 116 ATP. BINDING 156 156 ATP. BINDING 161 161 ATP. BINDING 165 165 ATP. BINDING 512 512 Agonist. BINDING 550 550 Agonist
Nucleotide Binding	NP_BIND 200 203 ATP. NP_BIND 211 212 ATP
Mutation	511 511 Y->A: Loss of sensitivity to capsaicin 550 550 T->I: Reduces sensitivity to capsaicin 40-fold