Uniprot ID: Q8TD08	Protein name : Mitogen-activated protein kinase 15	Gene : MAPK15 ERK7 ERK8
Protein Families : "Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily"	Squence Length : 544

Sequence	>Q8TD08 545 MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSSGTSREKGPEGVSPSQAHLHKPRADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQTALLGNGERPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAAQVANQALIRGDWNRGGGVRVASVQQVPPRLPPEARPGRRMFSTSALQGAQGGARALLGGYSQAYGTVCHSALGHLPLLEGHHV
Repeat regions	REPEAT 371 375 PXXXP motif REPEAT 378 382 PXXXP motif REPEAT 386 390 PXXXP motif regulates binding with chromatin and interaction with PCNA REPEAT 394 398 PXXXP motif regulates binding with chromatin and interaction with PCNA
Sequence region of repeats	371- 375 ADPQL 378- 382 RTPVQ 386- 390 PRPQS 394- 398 HDPAE
Domains	DOMAIN 13 304 Protein kinase
Function	"Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:22948227, PubMed:24618899, PubMed:29021280, PubMed:21847093, PubMed:20733054). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:20638370, PubMed:19166846). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936)"
Active Site	ACT_SITE 137 137 Proton acceptor
Motifs	MOTIF 175 177 TXY
Binding Site	BINDING 42 42 ATP
Nucleotide Binding	NP_BIND 19 27 ATP
Mutation	42 42 K->A: Not phosphorylated at Thr-175 and Tyr-177 42 42 K->R: Loss of autophosphorylation and activity 59 59 R->Q: Does not increase dopamine transporter activity 155 155 D->A: Unable to induce the formation of autophagosomal structures 175 175 T->A: Loss of autophosphorylation and activity when associated with F-177 177 177 Y->A: Loss of autophosphorylation and activity 177 177 Y->F: Does not rescues inhibition of O-glycosylation in MAPK15-depleted cells when associated with A-175 265 269 LDALL->ADAAA: Markedly decreases interaction with ESRRA when associated with A-281 and 284-A--A-285 281 285 LRRLL->ARRAA: Markedly decreases interaction with ESRRA when associated with A-265 and 268-A--A-269 300 300 Q->A: Impairs interaction with PCNA 340 343 YQMI->AQMA: Impairs interaction with GABARAP and MAP1LC3B 390 390 P->A: Impairs chromatin binding when associated with A-398 when associated with A-398 398 398 P->A: Impairs chromatin binding when associated with A-390 when associated with A-390

Q8TD08 Proteins with PXXXP Repeats