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Q8WX94 Proteins with LRR Repeats

Uniprot ID: Q8WX94	Protein name : "NACHT, LRR and PYD domains-containing protein 7 "	Gene : NLRP7 NALP7 NOD12 PYPAF3
Protein Families : NLRP family	Squence Length : 980

Sequence	>Q8WX94 981 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTIDCNASGATAPPCCDFFC
Repeat regions	REPEAT 614 638 LRR 1 REPEAT 674 697 LRR 2 REPEAT 760 784 LRR 3 REPEAT 788 810 LRR 4 REPEAT 817 840 LRR 5 REPEAT 845 868 LRR 6 REPEAT 874 897 LRR 7 REPEAT 902 928 LRR 8 REPEAT 933 957 LRR 9
Sequence region of repeats	614- 638 DLQKLSLQVAKGVFLENYMDFELDI 674- 697 NLKFLEVKQSFLSDSSVRILCDHV 760- 784 NLQYLRLGGHCATPEQWAEFFYVLK 788- 810 SLKHLRLSANVLLDEGAMLLYKT 817- 840 FLQMLSLENCRLTEASCKDLAAVL 845- 868 KLTHLCLAKNPIGDTGVKFLCEGL 874- 897 KLQTLVLQQCSITKLGCRYLSEAL 902- 928 SLTNLDLSINQIARGLWILCQALENPN 933- 957 HLRLKTYETNLEIKKLLEEVKEKNP
Domains	DOMAIN 1 93 Pyrin. DOMAIN 172 491 NACHT
Function	Inhibits CASP1/caspase-1-dependent IL1B secretion
Nucleotide Binding	NP_BIND 178 185 ATP
Disease	"DISEASE: Hydatidiform mole, recurrent, 1 (HYDM1) [MIM:231090]: A disorder characterized by excessive trophoblast development that produces a growing mass of tissue inside the uterus at the beginning of a pregnancy It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi Note=The disease is caused by mutations affecting the gene represented in this entry"