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Q8WXD0 Proteins with LRR Repeats
Uniprot ID: Q8WXD0
Protein name : Relaxin receptor 2
Gene : RXFP2 GPR106 GREAT LGR8
Protein Families : G-protein coupled receptor 1 family
Squence Length : 754
Sequence
>Q8WXD0 755 MIVFLVFKHLFSLRLITMFFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLPRAFHCDGKDDCGNGADEENCGDTSGWATIFGTVHGNANSVALTQECFLKQYPQCCDCKETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSVILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQRKSIFKIKKKSLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS
Repeat regions
REPEAT 138 159 LRR 1 REPEAT 162 183 LRR 2 REPEAT 186 207 LRR 3 REPEAT 210 231 LRR 4 REPEAT 234 255 LRR 5 REPEAT 258 279 LRR 6 REPEAT 282 303 LRR 7 REPEAT 306 327 LRR 8 REPEAT 330 351 LRR 9 REPEAT 354 375 LRR 10
Sequence region of repeats
138- 159 TLLSLKKNKIHSLPDKVFIKYT 162- 183 KKIFLQHNCIRHISRKAFFGLC 186- 207 QILYLNHNCITTLRPGIFKDLH 210- 231 TWLILDDNPITRISQRLFTGLN 234- 255 FFLSMVNNYLEALPKQMCAQMP 258- 279 NWVDLEGNRIKYLTNSTFLSCD 282- 303 TVLFLPRNQIGFVPEKTFSSLK 306- 327 GELDLSSNTITELSPHLFKDLK 330- 351 QKLNLSSNPLMYLHKNQFESLK 354- 375 QSLDLERIEIPNINTRMFQPMK
Domains
DOMAIN 44 81 LDL-receptor class A
Function
Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3)
Mutation
647 647 D->Y: Leads to constitutive increase of basal cAMP
Disease
"DISEASE: Cryptorchidism (CRYPTO) [MIM:219050]: One of the most frequent congenital abnormalities in humans, involving 2-5% of male births Cryptorchidism is associated with increased risk of infertility and testicular cancer Note=The disease is caused by mutations affecting the gene represented in this entry"