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Q8WYA6 Proteins with HEAT Repeats

Uniprot ID: Q8WYA6	Protein name : Beta-catenin-like protein 1	Gene : CTNNBL1 C20orf33 PP8304
Protein Families :	Squence Length : 563

Sequence	>Q8WYA6 564 MDVGELLSYQPNRGTKRPRDDEEEEQKMRRKQTGTRERGRYREEEMTVVEEADDDKKRLLQIIDRDGEEEEEEEEPLDESSVKKMILTFEKRSYKNQELRIKFPDNPEKFMESELDLNDIIQEMHVVATMPDLYHLLVELNAVQSLLGLLGHDNTDVSIAVVDLLQELTDIDTLHESEEGAEVLIDALVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKMPFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEHEEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQKRILGLLENF
Repeat regions	REPEAT 79 129 HEAT 1 REPEAT 134 176 HEAT 2 REPEAT 178 228 ARM 1 REPEAT 229 273 ARM 2 REPEAT 274 323 ARM 3 REPEAT 325 363 ARM 4 REPEAT 364 417 ARM 5
Sequence region of repeats	79- 129 SVKKMILTFEKRSYKNQELRIKFPDNPEKFMESELDLNDIIQEMHVVATMP 134- 176 LLVELNAVQSLLGLLGHDNTDVSIAVVDLLQELTDIDTLHESE
Function	Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis
Motifs	MOTIF 16 33 Nuclear localization signal. MOTIF 130 140 Nuclear export signal (NES)
Mutation	16 33 Missing: Nuclear and cytoplasmic localization 521 563 Missing: No change in NLS binding nor folding