BACK
HOME
Q96EY1 Proteins with CXXCXGXG Repeats
Uniprot ID: Q96EY1
Protein name : "DnaJ homolog subfamily A member 3, mitochondrial "
Gene : DNAJA3 HCA57 TID1
Protein Families :
Squence Length : 480
Sequence
>Q96EY1 481 MAARCSTRWLLVVVGTPRLPAISGRGARPPREGVVGAWLSRKLSVPAFASSLTSCGPRALLTLRPGVSLTGTKHNPFICTASFHTSAPLAKEDYYQILGVPRNASQKEIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDPGASGSQHSYWKGGPTVDPEELFRKIFGEFSSSSFGDFQTVFDQPQEYFMELTFNQAAKGVNKEFTVNIMDTCERCNGKGNEPGTKVQHCHYCGGSGMETINTGPFVMRSTCRRCGGRGSIIISPCVVCRGAGQAKQKKRVMIPVPAGVEDGQTVRMPVGKREIFITFRVQKSPVFRRDGADIHSDLFISIAQALLGGTARAQGLYETINVTIPPGTQTDQKIRMGGKGIPRINSYGYGDHYIHIKIRVPKRLTSRQQSLILSYAEDETDVEGTVNGVTLTSSGGSTMDSSAGSKARREAGEDEEGFLSKLKKMFTS
Repeat regions
REPEAT 236 243 CXXCXGXG motif REPEAT 253 260 CXXCXGXG motif REPEAT 275 282 CXXCXGXG motif REPEAT 289 296 CXXCXGXG motif
Sequence region of repeats
236- 243 RCNGKGNE 253- 260 YCGGSGME 275- 282 RCGGRGSI 289- 296 VCRGAGQA
Domains
DOMAIN 93 158 J
Function
"Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway"
Mutation
121 121 H->Q: Loss of modulation of apoptosis