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Q96HA7 Proteins with TPR Repeats
Uniprot ID: Q96HA7
Protein name : Tonsoku-like protein
Gene : TONSL IKBR NFKBIL2
Protein Families : Tonsoku family
Squence Length : 1378
Sequence
>Q96HA7 1379 MSLERELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERADDPLGCAVAHRKIGERLAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFESLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFMESECCVVIAQVLQDLGDFLAAKRALKKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLEEAEGRDPQGAMVICEQLGDLFSKAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLATTLGDMKDHHGAVRHYEEELRLRSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSCAQQAQRPQLQRQVLQHLHTVQLRLQPQEAPETETRLRELSVAEDEDEEEEAEEAAATAESEALEAGEVELSEGEDDTDGLTPQLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAASGQDPHSSQAFHTPSSLLFDPETSPPLSPCPEPPSNSTRLPEASQAHVRVSPGQAAPAMARPRRSRHGPASSSSSSEGEDSAGPARPSQKRPRCSATAQRVAAWTPGPASNREAATASTSRAAYQAAIRGVGSAQSRLGPGPPRGHSKALAPQAALIPEEECLAGDWLELDMPLTRSRRPRPRGTGDNRRPSSTSGSDSEESRPRARAKQVRLTCMQSCSAPVNAGPSSLASEPPGSPSTPRVSEPSGDSSAAGQPLGPAPPPPIRVRVQVQDHLFLIPVPHSSDTHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDLIPDVLQSNDEVLAEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVELQGLGLSFSACSLALDQAQLTPLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMPSLALLDLSSNHLGPEGLRQLAMGLPGQATLQSLEELDLSMNPLGDGCGQSLASLLHACPLLSTLRLQACGFGPSFFLSHQTALGSAFQDAEHLKTLSLSYNALGAPALARTLQSLPAGTLLHLELSSVAAGKGDSDLMEPVFRYLAKEGCALAHLTLSANHLGDKAVRDLCRCLSLCPSLISLDLSANPEISCASLEELLSTLQKRPQGLSFLGLSGCAVQGPLGLGLWDKIAAQLRELQLCSRRLCAEDRDALRQLQPSRPGPGECTLDHGSKLFFRRL
Repeat regions
REPEAT 27 60 TPR 1 REPEAT 67 100 TPR 2 REPEAT 107 147 TPR 3 REPEAT 162 195 TPR 4 REPEAT 202 235 TPR 5 REPEAT 242 275 TPR 6 REPEAT 311 344 TPR 7 REPEAT 352 385 TPR 8 REPEAT 528 557 ANK 1 REPEAT 561 590 ANK 2 REPEAT 597 626 ANK 3 REPEAT 1069 1093 LRR 1 REPEAT 1097 1122 LRR 2 REPEAT 1128 1151 LRR 3 REPEAT 1188 1212 LRR 4 REPEAT 1247 1270 LRR 5 REPEAT 1275 1300 LRR 6 REPEAT 1331 1354 LRR 7
Sequence region of repeats
27- 60 LCHQLGELLAGHGRYAEALEQHWQELQLRERADD 67- 100 AHRKIGERLAEMEDYPAALQHQHQYLELAHSLRN 107- 147 AWATIGRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELE 162- 195 LYLNLGLTFESLQQTALCNDYFRKSIFLAEQNHL 202- 235 ARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRK 242- 275 CCVVIAQVLQDLGDFLAAKRALKKAYRLGSQKPV 311- 344 ICEQLGDLFSKAGDFPRAAEAYQKQLRFAELLDR 352- 385 IHVSLATTLGDMKDHHGAVRHYEEELRLRSGNVL
Function
"Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold"