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Q9BRP4 Proteins with WD Repeats
Uniprot ID: Q9BRP4
Protein name : Proteasomal ATPase-associated factor 1
Gene : PAAF1 WDR71
Protein Families : WD repeat PAAF1/RPN14 family
Squence Length : 392
Sequence
>Q9BRP4 393 MAAPLRIQSDWAQALRKDEGEAWLSCHPPGKPSLYGSLTCQGIGLDGIPEVTASEGFTVNEINKKSIHISCPKENASSKFLAPYTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGNIYQLDVRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFIVQQDLDYVTELTGADCDPVYKVATWEKQIYTCCRDGLVRRYQLSDL
Repeat regions
REPEAT 82 121 WD 1 REPEAT 125 163 WD 2 REPEAT 167 205 WD 3 REPEAT 209 259 WD 4 REPEAT 270 308 WD 5 REPEAT 313 349 WD 6 REPEAT 353 389 WD 7
Sequence region of repeats
82- 121 YTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASN 125- 163 RRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAED 167- 205 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGR 209- 259 LGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDK 270- 308 QLVFLFIGSDAFNCCTFLSGFLLLAGTQDGNIYQLDVRS 313- 349 VQVIHRSGAPVLSLLSVRDGFIASQGDGSCFIVQQDL 353- 389 TELTGADCDPVYKVATWEKQIYTCCRDGLVRRYQLSD
Function
"Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation"