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Q9BU89 Proteins with HEAT Repeats
Uniprot ID: Q9BU89
Protein name : Deoxyhypusine hydroxylase
Gene : DOHH HLRC1
Protein Families : Deoxyhypusine hydroxylase family
Squence Length : 302
Sequence
>Q9BU89 303 MVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHETGRAFQYADGLEQLRGAPS
Repeat regions
REPEAT 54 80 HEAT-like PBS-type 1 REPEAT 87 113 HEAT-like PBS-type 2 REPEAT 174 200 HEAT-like PBS-type 3 REPEAT 205 231 HEAT-like PBS-type 4 REPEAT 238 264 HEAT-like PBS-type 5
Sequence region of repeats
54- 80 HELAYCLGQMQDARAIPMLVDVLQDTR 87- 113 HEAGEALGAIGDPEVLEILKQYSSDPV 174- 200 YRAMFALRNAGGEEAALALAEGLHCGS 205- 231 HEVGYVLGQLQHEAAVPQLAAALARCT 238- 264 HECAEALGAIARPACLAALQAHADDPE
Function
"Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine (PubMed:16533814, PubMed:16371467, PubMed:19706422). Hypusination is unique to mature eIF-5A factor and is essential for its function (By similarity)"
Mutation
56 56 H->A: Loss of deoxyhypusine monooxygenase activity 57 57 E->A: Loss of deoxyhypusine monooxygenase activity 86 86 M->A: Loss of iron-binding 86 86 M->L: No effect on iron-binding when associated with L-237 89 89 H->A: Loss of deoxyhypusine monooxygenase activity 90 90 E->A: Loss of deoxyhypusine monooxygenase activity 207 207 H->A: Loss of deoxyhypusine monooxygenase activity 208 208 E->A: Loss of deoxyhypusine monooxygenase activity 237 237 M->L: Decreased iron-binding when associated with L-86 240 240 H->A: Loss of deoxyhypusine monooxygenase activity 241 241 E->A: Loss of deoxyhypusine monooxygenase activity