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Q9H9E1 Proteins with ANK Repeats
Uniprot ID: Q9H9E1
Protein name : Ankyrin repeat family A protein 2
Gene : ANKRA2 ANKRA
Protein Families :
Squence Length : 313
Sequence
>Q9H9E1 314 MDTSTNLDIGAQLIVEECPSTYSLTGMPDIKIEHPLDPNSEEGSAQGVAMGMKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE
Repeat regions
REPEAT 148 180 ANK 1 REPEAT 181 213 ANK 2 REPEAT 214 246 ANK 3 REPEAT 247 279 ANK 4 REPEAT 280 313 ANK 5
Sequence region of repeats
148- 180 SLSVHQLAAQGEMLYLATRIEQENVINHTDEEG 181- 213 FTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGR 214- 246 ESALSLACSKGYTDIVKMLLDCGVDVNEYDWNG 247- 279 GTPLLYAVHGNHVKCVKMLLESGADPTIETDSG 280- 313 YNSMDLAVALGYRSVQQVIESHLLKLLQNIKE
Function
May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity)
Mutation
31 31 K->R: No effect on interaction with CCDC8 188 188 W->A: Loss of interaction with CCDC8 254 254 Y->A: Decreased affinity for HDAC4