Uniprot ID: Q9NZR2	Protein name : Low-density lipoprotein receptor-related protein 1B	Gene : LRP1B LRPDIT
Protein Families : LDLR family	Squence Length : 4599

Sequence	>Q9NZR2 4600 MSEFLLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEVDHDHNDGGLLDPGFMIDPTKARYIGGGPSAFKLPHTAPPIYLNSDLKGPLTAGPTNYSNPVYAKLYMDGQNCRNSLGSVDERKELLPKKIEIGIRETVA
Repeat regions	REPEAT 295 337 LDL-receptor class B 1 REPEAT 338 381 LDL-receptor class B 2 REPEAT 382 425 LDL-receptor class B 3 REPEAT 568 610 LDL-receptor class B 4 REPEAT 611 656 LDL-receptor class B 5 REPEAT 657 706 LDL-receptor class B 6 REPEAT 707 750 LDL-receptor class B 7 REPEAT 1300 1346 LDL-receptor class B 8 REPEAT 1347 1389 LDL-receptor class B 9 REPEAT 1390 1436 LDL-receptor class B 10 REPEAT 1437 1480 LDL-receptor class B 11 REPEAT 1481 1522 LDL-receptor class B 12 REPEAT 1618 1660 LDL-receptor class B 13 REPEAT 1661 1704 LDL-receptor class B 14 REPEAT 1705 1744 LDL-receptor class B 15 REPEAT 1745 1787 LDL-receptor class B 16 REPEAT 1922 1964 LDL-receptor class B 17 REPEAT 1965 2007 LDL-receptor class B 28 REPEAT 2008 2051 LDL-receptor class B 19 REPEAT 2052 2095 LDL-receptor class B 20 REPEAT 2239 2280 LDL-receptor class B 21 REPEAT 2281 2329 LDL-receptor class B 22 REPEAT 2330 2374 LDL-receptor class B 23 REPEAT 2375 2416 LDL-receptor class B 24 REPEAT 2417 2459 LDL-receptor class B 25 REPEAT 3055 3098 LDL-receptor class B 26 REPEAT 3099 3141 LDL-receptor class B 27 REPEAT 3142 3185 LDL-receptor class B 28 REPEAT 3186 3224 LDL-receptor class B 29 REPEAT 3225 3268 LDL-receptor class B 30 REPEAT 3933 3980 LDL-receptor class B 31 REPEAT 3981 4038 LDL-receptor class B 32 REPEAT 4039 4082 LDL-receptor class B 33 REPEAT 4083 4127 LDL-receptor class B 34
Sequence region of repeats	295- 337 LYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGK 338- 381 LFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKL 382- 425 VYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLY 568- 610 IYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNN 611- 656 LYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGW 657- 706 MYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNT 707- 750 LYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVF 1300- 1346 LYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGN 1347- 1389 IYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGI 1390- 1436 LFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKR 1437- 1480 IVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEV 1481- 1522 YWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQ 1618- 1660 LYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRN 1661- 1704 LYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGK 1705- 1744 LYWTDGNTINMANMDGSNSKILFQNQKEPVGLSIDYVENK 1745- 1787 LYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKK 1922- 1964 IYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGN 1965- 2007 IYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGL 2008- 2051 LFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENK 2052- 2095 LYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIY 2239- 2280 IFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDT 2281- 2329 LYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNL 2330- 2374 MFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEK 2375- 2416 LYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYI 2417- 2459 FWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDTN 3055- 3098 IYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKN 3099- 3141 LYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGY 3142- 3185 LYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRR 3186- 3224 LYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDY 3225- 3268 IYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQP 3933- 3980 IIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGN 3981- 4038 IYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGM 4039- 4082 MYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSER 4083- 4127 IYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIY
Domains	DOMAIN 31 70 LDL-receptor class A 1. DOMAIN 76 114 LDL-receptor class A 2. DOMAIN 116 154 EGF-like 1. DOMAIN 155 194 EGF-like 2. calcium-binding. DOMAIN 471 517 EGF-like 3. DOMAIN 794 834 EGF-like 4. DOMAIN 844 882 LDL-receptor class A 3. DOMAIN 885 923 LDL-receptor class A 4. DOMAIN 926 963 LDL-receptor class A 5. DOMAIN 966 1003 LDL-receptor class A 6. DOMAIN 1005 1043 LDL-receptor class A 7. DOMAIN 1052 1089 LDL-receptor class A 8. DOMAIN 1094 1132 LDL-receptor class A 9. DOMAIN 1135 1174 LDL-receptor class A 10. DOMAIN 1174 1213 EGF-like 5. DOMAIN 1214 1253 EGF-like 6. DOMAIN 1527 1570 EGF-like 7. DOMAIN 1834 1875 EGF-like 8. DOMAIN 2143 2183 EGF-like 9. DOMAIN 2464 2504 EGF-like 10. DOMAIN 2509 2548 LDL-receptor class A 11. DOMAIN 2551 2587 LDL-receptor class A 12. DOMAIN 2590 2626 LDL-receptor class A 13. DOMAIN 2629 2675 LDL-receptor class A 14. DOMAIN 2681 2717 LDL-receptor class A 15. DOMAIN 2719 2757 LDL-receptor class A 16. DOMAIN 2760 2800 LDL-receptor class A 17. DOMAIN 2804 2841 LDL-receptor class A 18. DOMAIN 2844 2885 LDL-receptor class A 19. DOMAIN 2890 2926 LDL-receptor class A 20. DOMAIN 2927 2967 EGF-like 11. DOMAIN 2968 3008 EGF-like 12. calcium-binding. DOMAIN 3273 3314 EGF-like 13. DOMAIN 3316 3353 LDL-receptor class A 21. DOMAIN 3356 3392 LDL-receptor class A 22. DOMAIN 3395 3432 LDL-receptor class A 23. DOMAIN 3435 3472 LDL-receptor class A 24. DOMAIN 3475 3511 LDL-receptor class A 25. DOMAIN 3514 3550 LDL-receptor class A 26. DOMAIN 3552 3588 LDL-receptor class A 27. DOMAIN 3593 3629 LDL-receptor class A 28. DOMAIN 3631 3668 LDL-receptor class A 29. DOMAIN 3673 3711 LDL-receptor class A 30. DOMAIN 3714 3752 LDL-receptor class A 31. DOMAIN 3761 3797 LDL-receptor class A 32. DOMAIN 3801 3843 EGF-like 14. DOMAIN 3844 3881 EGF-like 15. DOMAIN 4171 4208 EGF-like 16. DOMAIN 4213 4249 EGF-like 17. DOMAIN 4249 4285 EGF-like 18. DOMAIN 4285 4321 EGF-like 19. DOMAIN 4321 4357 EGF-like 20. DOMAIN 4357 4392 EGF-like 21. DOMAIN 4390 4427 EGF-like 22
Function	Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis
Motifs	MOTIF 4492 4495 Endocytosis signal. MOTIF 4559 4562 Endocytosis signal

Q9NZR2 Proteins with LDL-receptor Repeats