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Q9UJX3 Proteins with TPR Repeats
Uniprot ID: Q9UJX3
Protein name : Anaphase-promoting complex subunit 7
Gene : ANAPC7 APC7
Protein Families : APC7 family
Squence Length : 599
Sequence
>Q9UJX3 600 MDPGDAAILESSLRILYRLFESVLPPLPAALQSRMNVIDHVRDMAAAGLHSNVRLLSSLLLTMSNNNPELFSPPQKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPSTGNSASTPQSQCLPSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINMMLANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ
Repeat regions
REPEAT 135 168 TPR 1 REPEAT 203 236 TPR 2 REPEAT 237 270 TPR 3 REPEAT 271 304 TPR 4 REPEAT 373 406 TPR 5 REPEAT 407 440 TPR 6 REPEAT 441 475 TPR 7 REPEAT 476 508 TPR 8 REPEAT 509 542 TPR 9 REPEAT 543 565 TPR 10
Sequence region of repeats
135- 168 EVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPK 203- 236 AILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSV 237- 270 WIKAYAFVHTGDNSRAISTICSLEKKSLLRDNVD 271- 304 LLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIK 373- 406 ALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLD 407- 440 CYEGLIECYLASNSIREAMVMANNVYKTLGANAQ 441- 475 TLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIK 476- 508 AVVKKAELLSREQKYEDGIALLRNALANQSDCV 509- 542 LHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQK 543- 565 SLEGMQKMEKEESPTDATQEEDV
Function
"Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains"
Mutation
56 56 L->R: Loss of homodimerization when associated with K-60 60 60 L->K: Loss of homodimerization when associated with R-56