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Q9Y239 Proteins with LRR Repeats

Uniprot ID: Q9Y239	Protein name : Nucleotide-binding oligomerization domain-containing protein 1	Gene : NOD1 CARD4
Protein Families :	Squence Length : 953

Sequence	>Q9Y239 954 MEEQGHSEMEIIPSESHPHIQLLKSNRELLVTHIRNTQCLVDNLLKNDYFSAEDAEIVCACPTQPDKVRKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPWLLEIGFSPSLLTQSKVVVNTDPVSRYTQQLRHHLGRDSKFVLCYAQKEELLLEEIYMDTIMELVGFSNESLGSLNSLACLLDHTTGILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPLVLLANLLSGKLLKGASKLLTARTGIEVPRQFLRKKVLLRGFSPSHLRAYARRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKVYEDEKRIICF
Repeat regions	REPEAT 632 656 LRR 1 REPEAT 702 725 LRR 2 REPEAT 727 750 LRR 3 REPEAT 755 778 LRR 4 REPEAT 783 806 LRR 5 REPEAT 839 862 LRR 6 REPEAT 867 891 LRR 7 REPEAT 895 918 LRR 8 REPEAT 923 946 LRR 9
Sequence region of repeats	632- 656 SLPRVQVESFNQVQAMPTFIWMLRC 702- 725 KRLALDLDNNNLNDYGVRELQPCF 727- 750 RLTVLRLSVNQITDGGVKVLSEEL 755- 778 IVTYLGLYNNQITDVGARYVTKIL 783- 806 GLTHLKLGKNKITSEGGKYLALAV 839- 862 SLTTLSLASNGISTEGGKSLARAL 867- 891 SLEILWLTQNELNDEVAESLAEMLK 895- 918 TLKHLWLIQNQITAKGTAQLADAL 923- 946 GITEICLNGNLIKPEEAKVYEDEK
Domains	DOMAIN 15 105 CARD. DOMAIN 196 531 NACHT
Function	Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection
Nucleotide Binding	NP_BIND 202 209 ATP
Mutation	41 41 V->A: Abolishes interaction with RIPK2/RICK 41 41 V->Q: Abolishes caspase-9 activation 44 44 L->A: Abolishes activation of NF-kappa-B 48 48 D->K: Abolishes activation of NF-kappa-B 53 53 E->K: No effect on activation of NF-kappa-B 54 54 D->K: Abolishes activation of NF-kappa-B 56 56 E->K: Abolishes activation of NF-kappa-B 69 69 R->E: Abolishes activation of NF-kappa-B 208 208 K->R: Reduces caspase-9 activation 287 287 D->A: Reduced binding affinity for NLRP10 711 711 D->S: Does not associate with cell membrane 788 788 H->S: No effect on association with cell membrane 792 792 G->S: Does not associate with cell membrane 877 877 Q->S: Does not associate with cell membrane