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Q9Y3R4 Proteins with BNR Repeats

Uniprot ID: Q9Y3R4	Protein name : Sialidase-2	Gene : NEU2
Protein Families : Glycosyl hydrolase 33 family	Squence Length : 380

Sequence	>Q9Y3R4 381 MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYDAPTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLHDRARSLVVPAYAYRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVTLNARSHLRARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSGPGSPAQWLLYTHPTHSWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYEEIVFLMFTLKQAFPAEYLPQ
Repeat regions	REPEAT 127 138 BNR 1 REPEAT 197 208 BNR 2
Sequence region of repeats	127- 138 STDHGRTWSSPR 197- 208 SHDHGRTWARGH
Function	"Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides"
Active Site	ACT_SITE 46 46 Proton acceptor. ACT_SITE 334 334 Nucleophile. ACT_SITE 355 355
Motifs	MOTIF 20 23 FRIP motif
Binding Site	BINDING 21 21 Substrate. BINDING 41 41 Substrate. BINDING 179 179 Substrate. BINDING 181 181 Substrate. BINDING 218 218 Substrate. BINDING 237 237 Substrate. BINDING 304 304 Substrate
Mutation	"46 46 D->A: Loss of enzyme activity 218 218 E->A,Q: Loss of enzyme activity 270 270 Q->E: No effect on enzyme activity"