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Q9Y4P8 Proteins with WD Repeats

Uniprot ID: Q9Y4P8	Protein name : WD repeat domain phosphoinositide-interacting protein 2	Gene : WIPI2 CGI-50
Protein Families : WD repeat SVP1 family	Squence Length : 454

Sequence	>Q9Y4P8 455 MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYTDDLGAVGGACLEDEASALRLDEDSEHPPMILRTD
Repeat regions	REPEAT 15 60 WD 1 REPEAT 67 104 WD 2 REPEAT 110 142 WD 3 REPEAT 149 189 WD 4 REPEAT 193 232 WD 5 REPEAT 238 277 WD 6 REPEAT 320 359 WD 7
Sequence region of repeats	15- 60 FANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSSVD 67- 104 ECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKK 110- 142 NYSYSNTILAVKLNRQRLIVCLEESLYIHNIRD 149- 189 IRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTIN 193- 232 ANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPE 238- 277 EFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLET 320- 359 TVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDP
Function	"Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). May bind PtdIns3P.; Isoform 4: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella"
Motifs	MOTIF 241 244 FRRG motif
Mutation	126 126 R->E: Impairs interaction with ATG16L1 143 143 R->E: Decreasess interaction with ATG16L1 242 242 R->T: Impairs preautophagosomal localization when associated with T-243 243 243 R->T: Impairs preautophagosomal localization when associated with T-242