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Q9Y6U3 Proteins with Gelsolin-like Repeats
Uniprot ID: Q9Y6U3
Protein name : Adseverin
Gene : SCIN KIAA1905
Protein Families : Villin/gelsolin family
Squence Length : 715
Sequence
>Q9Y6U3 716 MARELYHEEFARAGKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRGFTYHLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGGLKYKAGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKANQVATGIRYNERKGRSELIVVEEGSEPSELIKVLGEKPELPDGGDDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW
Repeat regions
REPEAT 27 76 Gelsolin-like 1 REPEAT 148 188 Gelsolin-like 2 REPEAT 265 307 Gelsolin-like 3 REPEAT 398 451 Gelsolin-like 4 REPEAT 523 564 Gelsolin-like 5 REPEAT 626 668 Gelsolin-like 6
Sequence region of repeats
27- 76 LVPVPQSAHGDFYVGDAYLVLHTAKTSRGFTYHLHFWLGKECSQDESTAA 148- 188 ATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKA 265- 307 AEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAA 398- 451 IWRVENNGRIQVDQNSYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTTS 523- 564 IVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGA 626- 668 IEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKES
Function
"Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009)"
Mutation
310 310 M->D: Increases calcium-independent actin-severing activity 314 314 E->S: Increases calcium-independent actin-severing activity 455 455 F->D: Loss of actin-binding