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O14776 Proteins WW domain Repeats
Uniprot ID:O14776
Protein name: Transcription elongation regulator 1
Gene : TCERG1 CA150 TAF2S
Protein Family:
Squence Length : 1098
Sequnce
>O14776 1099 MAERGGDGGESERFNPGELRMAQQQALRFRGPAPPPNAVMRGPPPLMRPPPPFGMMRGPPPPPRPPFGRPPFDPNMPPMPPPGGIPPPMGPPHLQRPPFMPPPMSSMPPPPGMMFPPGMPPVTAPGTPALPPTEEIWVENKTPDGKVYYYNARTRESAWTKPDGVKVIQQSELTPMLAAQAQVQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQVQAQVQAQVQAQAVGASTPTTSSPAPAVSTSTSSSTPSSTTSTTTTATSVAQTVSTPTTQDQTPSSAVSVATPTVSVSTPAPTATPVQTVPQPHPQTLPPAVPHSVPQPTTAIPAFPPVMVPPFRVPLPGMPIPLPGVAMMQIVSCPYVKTVATTKTGVLPGMAPPIVPMIHPQVAIAASPATLAGATAVSEWTEYKTADGKTYYYNNRTLESTWEKPQELKEKEKLEEKIKEPIKEPSEEPLPMETEEEDPKEEPIKEIKEEPKEEEMTEEEKAAQKAKPVATAPIPGTPWCVVWTGDERVFFYNPTTRLSMWDRPDDLIGRADVDKIIQEPPHKKGMEELKKLRHPTPTMLSIQKWQFSMSAIKEEQELMEEINEDEPVKAKKRKRDDNKDIDSEKEAAMEAEIKAARERAIVPLEARMKQFKDMLLERGVSAFSTWEKELHKIVFDPRYLLLNPKERKQVFDQYVKTRAEEERREKKNKIMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKDSRFKAIEKMKDREALFNEFVAAARKKEKEDSKTRGEKIKSDFFELLSNHHLDSQSRWSKVKDKVESDPRYKAVDSSSMREDLFKQYIEKIAKNLDSEKEKELERQARIEASLREREREVQKARSEQTKEIDREREQHKREEAIQNFKALLSDMVRSSDVSWSDTRRTLRKDHRWESGSLLEREEKEKLFNEHIEALTKKKREHFRQLLDETSAITLTSTWKEVKKIIKEDPRCIKFSSSDRKKQREFEEYIRDKYITAKADFRTLLKETKFITYRSKKLIQESDQHLKDVEKILQNDKRYLVLDCVPEERRKLIVAYVDDLDRRGPPPPPTASEPTRRSTK
Domains
DOMAIN 131 164 WW 1 DOMAIN 429 462 WW 2 DOMAIN 528 561 WW 3 DOMAIN 659 712 FF 1 DOMAIN 725 779 FF 2 DOMAIN 791 846 FF 3 DOMAIN 896 952 FF 4 DOMAIN 954 1010 FF 5 DOMAIN 1012 1077 FF 6
WW sequence regions
131 - 164 TEEIWVENKTPDGKVYYYNARTRESAWTKPDGVK 429 - 462 AVSEWTEYKTADGKTYYYNNRTLESTWEKPQELK 528 - 561 PGTPWCVVWTGDERVFFYNPTTRLSMWDRPDDLI
Function
Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter
Motifs
MOTIF 626 630 Nuclear localization signal
Mutation
148 150 YYY->AAA: Reduces repression of transcription by 35% when associated with 446-AAA-448 446 448 YYY->AAA: Loss of interaction with SF1 when associated with 148-AAA-150 545 547 FFY->AAA: No effect