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O43291 Proteins BPTI/Kunitz inhibitor domain Repeats
Uniprot ID:O43291
Protein name: Kunitz-type protease inhibitor 2
Gene : SPINT2 HAI2 KOP
Protein Family:
Squence Length : 252
Sequnce
>O43291 253 MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERALRTVWSSGDDKEQLVKNTYVL
Domains
DOMAIN 38 88 BPTI/Kunitz inhibitor 1 DOMAIN 133 183 BPTI/Kunitz inhibitor 2
BPTI/Kunitz inhibitor sequence regions
38 - 88 VSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCAT 133 - 183 ANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFR
Function
"Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa"
Disease
"DISEASE: Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies (DIAR3) [MIM:270420]: A disease characterized by life-threatening secretory diarrhea, severe metabolic acidosis and hyponatremia Hyponatremia is secondary to extraordinarily high fecal sodium loss, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune and endocrine causes Note=The disease is caused by mutations affecting the gene represented in this entry"