HOME
BACK
O60663 Proteins LIM zinc-binding domain Repeats
Uniprot ID:O60663
Protein name: LIM homeobox transcription factor 1-beta
Gene : LMX1B
Protein Family:
Squence Length : 402
Sequnce
>O60663 403 MDIATGPESLERCFPRGQTDCAKMLDGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQRPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYEKEKDLLSSVSPDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQEVLSSRMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGDHMNPYGNDSIFHDIDSDTSLTSLSDCFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS
Domains
DOMAIN 56 106 LIM zinc-binding 1 DOMAIN 115 168 LIM zinc-binding 2
LIM zinc-binding sequence regions
56 - 106 GCQRPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQ 115 - 168 GCMEKIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYE
Function
Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels
Disease
DISEASE: Nail-patella syndrome (NPS) [MIM:161200]: Disease that cause abnormal skeletal patterning and renal dysplasia Note=The disease is caused by mutations affecting the gene represented in this entry