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O75074 Proteins LDL-receptor class A domain Repeats
Uniprot ID:O75074
Protein name: Low-density lipoprotein receptor-related protein 3
Gene : LRP3
Protein Family:LDLR family
Squence Length : 770
Sequnce
>O75074 771 MEKRAAAGLEGAPGARAQLAVVCLVNIFLTGRLSSAVPALAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVCGLLLVIALGCAFKLYSLRTQEYRAFETQMTRLEAEFVRREAPPSYGQLIAQGLIPPVEDFPVYSASQASVLQNLRTAMRRQMRRHASRRGPSRRRLGRLWNRLFHRPRAPRGQIPLLTAARPSQTVLGDGFLQPAPGAAPDPPAPLMDTGSTRAAGDRPPSAPGRAPEVGPSGPPLPSGLRDPECRPVDKDRKVCREPLVDGPAPADAPREPCSAQDPHPQVSTASSTLGPHSPEPLGVCRNPPPPCSPMLEASDDEALLVC
Domains
DOMAIN 43 159 CUB 1 DOMAIN 165 201 LDL-receptor class A 1 DOMAIN 211 250 LDL-receptor class A 2 DOMAIN 254 365 CUB 2 DOMAIN 415 453 LDL-receptor class A 3 DOMAIN 454 490 LDL-receptor class A 4
LDL-receptor class A sequence regions
165 - 201 QADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAP 211 - 250 PGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDL 415 - 453 PPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSC 454 - 490 QPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAA
Function
"Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro"