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O75093 Proteins EGF-like domain Repeats
Uniprot ID:O75093
Protein name: Slit homolog 1 protein
Gene : SLIT1 KIAA0813 MEGF4 SLIL1
Protein Family:
Squence Length : 1534
Sequnce
>O75093 1535 MALTPGWGSSAGPVRPELWLLLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYINNELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTKCGCALCA
Domains
DOMAIN 34 61 LRRNT DOMAIN 215 265 LRRCT 1 DOMAIN 273 309 LRRNT 2 DOMAIN 439 489 LRRCT 2 DOMAIN 504 540 LRRNT 3 DOMAIN 671 721 LRRCT 3 DOMAIN 725 761 LRRNT 4 DOMAIN 866 916 LRRCT 4 DOMAIN 927 962 EGF-like 1 DOMAIN 964 1003 EGF-like 2 DOMAIN 1005 1041 EGF-like 3 DOMAIN 1043 1081 EGF-like 4 DOMAIN 1083 1119 EGF-like 5 DOMAIN 1127 1163 EGF-like 6 DOMAIN 1166 1339 Laminin G-like DOMAIN 1340 1374 EGF-like 7 DOMAIN 1377 1413 EGF-like 8 DOMAIN 1418 1454 EGF-like 9 DOMAIN 1459 1534 CTCK
EGF-like sequence regions
927 - 962 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVS 964 - 1003 DSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVN 1005 - 1041 DDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQL 1043 - 1081 DLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSEN 1083 - 1119 DDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIP 1127 - 1163 SPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKL 1340 - 1374 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQP 1377 - 1413 GPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQA 1418 - 1454 EPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE
Function
"Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb"