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O75689 Proteins PH domain Repeats
Uniprot ID:O75689
Protein name: Arf-GAP with dual PH domain-containing protein 1
Gene : ADAP1 CENTA1
Protein Family:
Squence Length : 374
Sequnce
>O75689 375 MAKERRRAVLELLQRPGNARCADCGAPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARARFESKVPSFYYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRNDAKEPKAVMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGAGDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKFLFACETESDQREWVAAFQKAVDRPMLPQEYAVEAHFKHKP
Domains
DOMAIN 7 126 Arf-GAP DOMAIN 129 230 PH 1 DOMAIN 252 356 PH 2
PH sequence regions
129 - 230 YREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRNDAKEPKAVMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHY 252 - 356 LKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKFLFACETESDQREWVAAFQKAVDRP
Function
"GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4)"
Mutation
21 21 C->A: Loss of GTPase-activating activity 24 24 C->A: Loss of GTPase-activating activity 149 149 R->C: 40-45% reduction in PtdInsP2 3-kinase dependent membrane localization when associated with C-273 273 273 R->C: 70% reduction in PtdInsP2 3-kinase dependent membrane localization when associated with C-149