HOME
BACK
O76003 Proteins Glutaredoxin domain Repeats
Uniprot ID:O76003
Protein name: Glutaredoxin-3
Gene : GLRX3 PICOT TXNL2 HUSSY-22
Protein Family:
Squence Length : 335
Sequnce
>O76003 336 MAAGAAEAAVAAVEEVGSAGQFEELLRLKAKSLLVVHFWAPWAPQCAQMNEVMAELAKELPQVSFVKLEAEGVPEVSEKYEISSVPTFLFFKNSQKIDRLDGAHAPELTKKVQRHASSGSFLPSANEHLKEDLNLRLKKLTHAAPCMLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSFDIFSDEEVRQGLKAYSSWPTYPQLYVSGELIGGLDIIKELEASEELDTICPKAPKLEERLKVLTNKASVMLFMKGNKQEAKCGFSKQILEILNSTGVEYETFDILEDEEVRQGLKAYSNWPTYPQLYVKGELVGGLDIVKELKENGELLPILRGEN
Domains
DOMAIN 2 117 Thioredoxin DOMAIN 144 236 Glutaredoxin 1 DOMAIN 237 335 Glutaredoxin 2
Glutaredoxin sequence regions
144 - 236 CMLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSFDIFSDEEVRQGLKAYSSWPTYPQLYVSGELIGGLDIIKELEASEELDTICPKAPKLEER 237 - 335 LKVLTNKASVMLFMKGNKQEAKCGFSKQILEILNSTGVEYETFDILEDEEVRQGLKAYSNWPTYPQLYVKGELVGGLDIVKELKENGELLPILRGEN
Function
"Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity"
Mutation
159 159 C->S: Loss of 2Fe-2S-binding when associated with S-261 when associated with 197-D-A-198 197 198 WP->DA: Loss of 2Fe-2S-binding and interaction with BOLA2 when associated with S-159 261 261 C->S: Loss of 2Fe-2S-binding when associated with S-159 when associated with 299-D-A-300 299 300 WP->DA: Loss of 2Fe-2S-binding and interaction with BOLA2 when associated with S-261