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O95633 Proteins Follistatin-like domain Repeats
Uniprot ID:O95633
Protein name: Follistatin-related protein 3
Gene : FSTL3 FLRG UNQ674/PRO1308
Protein Family:
Squence Length : 263
Sequnce
>O95633 264 MRPGAPGPLWPLPWGALAWAVGFVSSMGSGNPAPGGVCWLQQGQEATCSLVLQTDVTRAECCASGNIDTAWSNLTHPGNKINLLGFLGLVHCLPCKDSCDGVECGPGKACRMLGGRPRCECAPDCSGLPARLQVCGSDGATYRDECELRAARCRGHPDLSVMYRGRCRKSCEHVVCPRPQSCVVDQTGSAHCVVCRAAPCPVPSSPGQELCGNNNVTYISSCHMRQATCFLGRSIGVRHAGSCAGTPEEPPGGESAEEEENFV
Domains
DOMAIN 36 107 TB DOMAIN 99 119 Follistatin-like 1 DOMAIN 113 169 Kazal-like 1 DOMAIN 170 193 Follistatin-like 2 DOMAIN 189 245 Kazal-like 2
Follistatin-like sequence regions
99 - 119 GVECGPGKACRMLGGRPRCEC 170 - 193 EHVVCPRPQSCVVDQTGSAHCVVC
Function
"Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10"
Mutation
27 27 M->A: Nuclear localization
Disease
DISEASE: Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia Translocation t(11;19)(q13;p13) with CCDN1