HOME
BACK
P01133 Proteins EGF-like domain Repeats
Uniprot ID:P01133
Protein name: Pro-epidermal growth factor
Gene : EGF
Protein Family:
Squence Length : 1207
Sequnce
>P01133 1208 MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGMGTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ
Domains
DOMAIN 314 355 EGF-like 1 DOMAIN 356 396 EGF-like 2 calcium-binding DOMAIN 397 437 EGF-like 3 DOMAIN 435 477 EGF-like 4 DOMAIN 741 781 EGF-like 5 DOMAIN 831 869 EGF-like 6 DOMAIN 870 911 EGF-like 7 calcium-binding DOMAIN 912 952 EGF-like 8 calcium-binding DOMAIN 972 1013 EGF-like 9
EGF-like sequence regions
314 - 355 KLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDV 356 - 396 NECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQL 397 - 437 VSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGC 435 - 477 SGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAAS 741 - 781 DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLAL 831 - 869 DDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDI 870 - 911 DECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDI 912 - 952 DECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDS 972 - 1013 SECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYR
Function
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941)
Disease
"DISEASE: Hypomagnesemia 4 (HOMG4) [MIM:611718]: A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes Note=The disease is caused by mutations affecting the gene represented in this entry"