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P02746 Proteins Collagen-like domain Repeats
Uniprot ID:P02746
Protein name: Complement C1q subcomponent subunit B
Gene : C1QB
Protein Family:
Squence Length : 253
Sequnce
>P02746 254 MMMKIPWGSIPVLMLLLLLGLIDISQAQLSCTGPPAIPGIPGIPGTPGPDGQPGTPGIKGEKGLPGLAGDHGEFGEKGDPGIPGNPGKVGPKGPMGPKGGPGAPGAPGPKGESGDYKATQKIAFSATRTINVPLRRDQTIRFDHVITNMNNNYEPRSGKFTCKVPGLYYFTYHASSRGNLCVNLMRGRERAQKVVTFCDYAYNTFQVTTGGMVLKLEQGENVFLQATDKNSLLGMEGANSIFSGFLLFPDMEA
Domains
DOMAIN 37 86 Collagen-like 1 DOMAIN 60 114 Collagen-like 2 DOMAIN 117 253 C1q
Collagen-like sequence regions
37 - 86 GIPGIPGTPGPDGQPGTPGIKGEKGLPGLAGDHGEFGEKGDPGIPGNPGK 60 - 114 KGLPGLAGDHGEFGEKGDPGIPGNPGKVGPKGPMGPKGGPGAPGAPGPKGESGDY
Function
"C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes"
Disease
DISEASE: Complement component C1q deficiency (C1QD) [MIM:613652]: A disorder caused by impaired activation of the complement classical pathway It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis Note=The disease is caused by mutations affecting the gene represented in this entry