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P03973 Proteins WAP domain Repeats
Uniprot ID:P03973
Protein name: Antileukoproteinase
Gene : SLPI WAP4 WFDC4
Protein Family:
Squence Length : 132
Sequnce
>P03973 133 MKSSGLFPFLVLLALGTLAPWAVEGSGKSFKAGVCPPKKSAQCLRYKKPECQSDWQCPGKKRCCPDTCGIKCLDPVDTPNPTRRKPGKCPVTYGQCLMLNPPNFCEMDGQCKRDLKCCMGMCGKSCVSPVKA
Domains
DOMAIN 28 76 WAP 1 DOMAIN 82 130 WAP 2
WAP sequence regions
28 - 76 FKAGVCPPKKSAQCLRYKKPECQSDWQCPGKKRCCPDTCGIKCLDPVDT 82 - 130 RKPGKCPVTYGQCLMLNPPNFCEMDGQCKRDLKCCMGMCGKSCVSPVKA
Function
"Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563, PubMed:10702419, PubMed:24121345). Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:10702419, PubMed:24352879). Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (PubMed:24352879)"
Mutation
"45 45 R->G: No significant effect on inhibition of elastase, trypsin and chymotrypsin 45 45 R->M,V: No significant effect on inhibition of elastase, trypsin and chymotrypsin 97 97 L->F: Increases inhibition of chymotrypsin 97 97 L->G: Reduced inhibition of elastase 97 97 L->K,R: Strongly reduced inhibition of elastase 98 98 M->G: No significant effect on inhibition of elastase, trypsin and chymotrypsin 99 99 L->G: No significant effect on inhibition of elastase, trypsin and chymotrypsin"