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P09012 Proteins RRM domain Repeats
Uniprot ID:P09012
Protein name: U1 small nuclear ribonucleoprotein A
Gene : SNRPA
Protein Family:RRM U1 A/B'' family
Squence Length : 282
Sequnce
>P09012 283 MAVPETRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDILVSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFVERDRKREKRKPKSQETPATKKAVQGGGATPVVGAVQGPVPGMPPMTQAPRIMHHMPGQPPYMPPPGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEETNELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMKISFAKK
Domains
DOMAIN 10 89 RRM 1 DOMAIN 208 282 RRM 2
RRM sequence regions
10 - 89 IYINNLNEKIKKDELKKSLYAIFSQFGQILDILVSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDS 208 - 282 LFLTNLPEETNELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMKISFAKK
Function
"Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs"
Mutation
11 11 T->V: Abolishes RNA binding 13 13 Y->F: Substantially reduces RNA binding 15 15 N->V: Abolishes RNA binding 16 16 N->V: Substantially reduces RNA binding 52 52 R->Q: Abolishes RNA binding