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P10646 Proteins BPTI/Kunitz inhibitor domain Repeats
Uniprot ID:P10646
Protein name: Tissue factor pathway inhibitor
Gene : TFPI LACI TFPI1
Protein Family:
Squence Length : 304
Sequnce
>P10646 305 MIYTMKKVHALWASVCLLLNLAPAPLNADSEEDEEHTIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRDNANRIIKTTLQQEKPDFCFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPNGFQVDNYGTQLNAVNNSLTPQSTKVPSLFEFHGPSWCLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKGFIQRISKGGLIKTKRKRKKQRVKIAYEEIFVKNM
Domains
DOMAIN 54 104 BPTI/Kunitz inhibitor 1 DOMAIN 125 175 BPTI/Kunitz inhibitor 2 DOMAIN 217 267 BPTI/Kunitz inhibitor 3
BPTI/Kunitz inhibitor sequence regions
54 - 104 FKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTR 125 - 175 LEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICED 217 - 267 TPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKK
Function
"Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma"
Mutation
64 64 K->I: Abolishes inhibition of VII(a)/TF 135 135 R->L: Abolishes inhibition of X(a) 227 227 R->L: Abolishes inhibition of VII(a)/TF