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P16333 Proteins SH3 domain Repeats
Uniprot ID:P16333
Protein name: Cytoplasmic protein NCK1
Gene : NCK1 NCK
Protein Family:
Squence Length : 377
Sequnce
>P16333 378 MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAPIFTSEQGEKLYLVKHLS
Domains
DOMAIN 2 61 SH3 1 DOMAIN 106 165 SH3 2 DOMAIN 190 252 SH3 3 DOMAIN 282 376 SH2
SH3 sequence regions
2 - 61 EVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSAR 106 - 165 NMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSP 190 - 252 LHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNP
Function
"Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors"
Mutation
38 38 W->K: Small decrease in RASA1-binding when associated with K-143 and K-229 143 143 W->K: No effect on RASA1-binding when associated with K-38 and K-229 229 229 W->K: Small decrease in RASA1-binding when associated with K-38 and K-229 308 308 R->K: No effect on RASA1-binding