HOME
BACK
P22105 Proteins EGF-like domain Repeats
Uniprot ID:P22105
Protein name: Tenascin-X
Gene : TNXB HXBL TNX TNXB1 TNXB2 XB
Protein Family:Tenascin family
Squence Length : 4242
Sequnce
>P22105 4243 MMPAQYALTSSLVLLVLLSTARAGPFSSRSNVTLPAPRPPPQPGGHTVGAGVGSPSSQLYEHTVEGGEKQVVFTHRINLPPSTGCGCPPGTEPPVLASEVQALRVRLEILEELVKGLKEQCTGGCCPASAQAGTGQTDVRTLCSLHGVFDLSRCTCSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSCGWPSCPGDCQGRGRCVQGVCVCRAGFSGPDCSQRSCPRGCSQRGRCEGGRCVCDPGYTGDDCGMRSCPRGCSQRGRCENGRCVCNPGYTGEDCGVRSCPRGCSQRGRCKDGRCVCDPGYTGEDCGTRSCPWDCGEGGRCVDGRCVCWPGYTGEDCSTRTCPRDCRGRGRCEDGECICDTGYSGDDCGVRSCPGDCNQRGRCEDGRCVCWPGYTGTDCGSRACPRDCRGRGRCENGVCVCNAGYSGEDCGVRSCPGDCRGRGRCESGRCMCWPGYTGRDCGTRACPGDCRGRGRCVDGRCVCNPGFTGEDCGSRRCPGDCRGHGLCEDGVCVCDAGYSGEDCSTRSCPGGCRGRGQCLDGRCVCEDGYSGEDCGVRQCPNDCSQHGVCQDGVCICWEGYVSEDCSIRTCPSNCHGRGRCEEGRCLCDPGYTGPTCATRMCPADCRGRGRCVQGVCLCHVGYGGEDCGQEEPPASACPGGCGPRELCRAGQCVCVEGFRGPDCAIQTCPGDCRGRGECHDGSCVCKDGYAGEDCGEEVPTIEGMRMHLLEETTVRTEWTPAPGPVDAYEIQFIPTTEGASPPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGTSWGLPASKTITTMIDGPQDLRVVAVTPTTLELGWLRPQAEVDRFVVSYVSAGNQRVRLEVPPEADGTLLTDLMPGVEYVVTVTAERGRAVSYPASVRANTGSSPLGLLGTTDEPPPSGPSTTQGAQAPLLQQRPQELGELRVLGRDETGRLRVVWTAQPDTFAYFQLRMRVPEGPGAHEEVLPGDVRQALVPPPPPGTPYELSLHGVPPGGKPSDPIIYQGIMDKDEEKPGKSSGPPRLGELTVTDRTSDSLLLRWTVPEGEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVGKKRHGPLVAEAKILPQSDPSPGTPPHLGNLWVTDPTPDSLHLSWTVPEGQFDTFMVQYRDRDGRPQVVPVEGPERSFVVSSLDPDHKYRFTLFGIANKKRYGPLTADGTTAPERKEEPPRPEFLEQPLLGELTVTGVTPDSLRLSWTVAQGPFDSFMVQYKDAQGQPQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGRQRVGPESVVAKTAPQEDVDETPSPTELGTEAPESPEEPLLGELTVTGSSPDSLSLFWTVPQGSFDSFTVQYKDRDGRPRAVRVGGKESEVTVGGLEPGHKYKMHLYGLHEGQRVGPVSAVGVTAPQQEETPPATESPLEPRLGELTVTDVTPNSVGLSWTVPEGQFDSFIVQYKDKDGQPQVVPVAADQREVTVYNLEPERKYKMNMYGLHDGQRMGPLSVVIVTAPLPPAPATEASKPPLEPRLGELTVTDITPDSVGLSWTVPEGEFDSFVVQYKDRDGQPQVVPVAADQREVTIPDLEPSRKYKFLLFGIQDGKRRSPVSVEAKTVARGDASPGAPPRLGELWVTDPTPDSLRLSWTVPEGQFDSFVVQFKDKDGPQVVPVEGHERSVTVTPLDAGRKYRFLLYGLLGKKRHGPLTADGTTEARSAMDDTGTKRPPKPRLGEELQVTTVTQNSVGLSWTVPEGQFDSFVVQYKDRDGQPQVVPVEGSLREVSVPGLDPAHRYKLLLYGLHHGKRVGPISAVAITAGREETETETTAPTPPAPEPHLGELTVEEATSHTLHLSWMVTEGEFDSFEIQYTDRDGQLQMVRIGGDRNDITLSGLESDHRYLVTLYGFSDGKHVGPVHVEALTVPEEEKPSEPPTATPEPPIKPRLGELTVTDATPDSLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEEGVTISGLEPDHKYKMNLYGFHGGQRMGPVSVVGVTAAEEETPSPTEPSMEAPEPAEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSAVGVTAPEEESPDAPLAKLRLGQMTVRDITSDSLSLSWTVPEGQFDHFLVQFKNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPVSAVGLTAPGKDEEMAPASTEPPTPEPPIKPRLEELTVTDATPDSLSLSWTVPEGQFDHFLVQYKNGDGQPKATRVPGHEDRVTISGLEPDNKYKMNLYGFHGGQRVGPVSAIGVTAAEEETPSPTEPSMEAPEPPEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTAPQEDVDETPSPTEPGTEAPGPPEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQAVRVGGQESKVTVRGLEPGRKYKMHLYGLHEGRRLGPVSAVGVTEDEAETTQAVPTMTPEPPIKPRLGELTMTDATPDSLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPISVIGVTAAEEETPSPTELSTEAPEPPEEPLLGELTVTGSSPDSLSLSWTIPQGHFDSFTVQYKDRDGRPQVMRVRGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTEDEAETTQAVPTTTPEPPNKPRLGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRNGDGQPKVVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPISVIGVTAAEEETPAPTEPSTEAPEPPEEPLLGELTVTGSSPDSLSLSWTIPQGRFDSFTVQYKDRDGRPQVVRVRGEESEVTVGGLEPGCKYKMHLYGLHEGQRVGPVSAVGVTAPKDEAETTQAVPTMTPEPPIKPRLGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPVSAIGVTEEETPSPTEPSTEAPEAPEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGQPQVVRVRGEESEVTVGGLEPGRKYKMHLYGLHEGQRVGPVSTVGITAPLPTPLPVEPRLGELAVAAVTSDSVGLSWTVAQGPFDSFLVQYRDAQGQPQAVPVSGDLRAVAVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAPDTKPSPRLGELTVTDATPDSVGLSWTVPEGEFDSFVVQYKDKDGRLQVVPVAANQREVTVQGLEPSRKYRFLLYGLSGRKRLGPISADSTTAPLEKELPPHLGELTVAEETSSSLRLSWTVAQGPFDSFVVQYRDTDGQPRAVPVAADQRTVTVEDLEPGKKYKFLLYGLLGGKRLGPVSALGMTAPEEDTPAPELAPEAPEPPEEPRLGVLTVTDTTPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPYRFLLYGLHEGKRLGPLSAEGTTGLAPAGQTSEESRPRLSQLSVTDVTTSSLRLNWEAPPGAFDSFLLRFGVPSPSTLEPHPRPLLQRELMVPGTRHSAVLRDLRSGTLYSLTLYGLRGPHKADSIQGTARTLSPVLESPRDLQFSEIRETSAKVNWMPPPSRADSFKVSYQLADGGEPQSVQVDGQARTQKLQGLIPGARYEVTVVSVRGFEESEPLTGFLTTVPDGPTQLRALNLTEGFAVLHWKPPQNPVDTYDVQVTAPGAPPLQAETPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPASITFTTGLEAPRDLEAKEVTPRTALLTWTEPPVRPAGYLLSFHTPGGQNQEILLPGGITSHQLLGLFPSTSYNARLQAMWGQSLLPPVSTSFTTGGLRIPFPRDCGEEMQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSMRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG
Domains
DOMAIN 156 168 EGF-like 1 incomplete DOMAIN 183 213 EGF-like 2 DOMAIN 214 244 EGF-like 3 DOMAIN 245 275 EGF-like 4 DOMAIN 276 306 EGF-like 5 DOMAIN 307 337 EGF-like 6 DOMAIN 338 368 EGF-like 7 DOMAIN 369 399 EGF-like 8 DOMAIN 400 430 EGF-like 9 DOMAIN 431 461 EGF-like 10 DOMAIN 462 492 EGF-like 11 DOMAIN 493 523 EGF-like 12 DOMAIN 524 554 EGF-like 13 DOMAIN 555 585 EGF-like 14 DOMAIN 586 616 EGF-like 15 DOMAIN 617 647 EGF-like 16 DOMAIN 648 679 EGF-like 17 DOMAIN 684 714 EGF-like 18 DOMAIN 715 746 EGF-like 19 DOMAIN 959 1051 Fibronectin type-III 1 DOMAIN 1064 1153 Fibronectin type-III 2 DOMAIN 1161 1249 Fibronectin type-III 3 DOMAIN 1263 1352 Fibronectin type-III 4 DOMAIN 1374 1468 Fibronectin type-III 5 DOMAIN 1476 1572 Fibronectin type-III 6 DOMAIN 1574 1669 Fibronectin type-III 7 DOMAIN 1674 1764 Fibronectin type-III 8 DOMAIN 1778 1868 Fibronectin type-III 9 DOMAIN 1883 1971 Fibronectin type-III 10 DOMAIN 1989 2089 Fibronectin type-III 11 DOMAIN 2097 2185 Fibronectin type-III 12 DOMAIN 2196 2296 Fibronectin type-III 13 DOMAIN 2305 2398 Fibronectin type-III 14 DOMAIN 2408 2502 Fibronectin type-III 15 DOMAIN 2519 2617 Fibronectin type-III 16 DOMAIN 2625 2723 Fibronectin type-III 17 DOMAIN 2733 2838 Fibronectin type-III 18 DOMAIN 2839 2937 Fibronectin type-III 19 DOMAIN 2947 3040 Fibronectin type-III 20 DOMAIN 3060 3151 Fibronectin type-III 21 DOMAIN 3166 3258 Fibronectin type-III 22 DOMAIN 3262 3353 Fibronectin type-III 23 DOMAIN 3355 3444 Fibronectin type-III 24 DOMAIN 3449 3542 Fibronectin type-III 25 DOMAIN 3551 3645 Fibronectin type-III 26 DOMAIN 3655 3752 Fibronectin type-III 27 DOMAIN 3756 3845 Fibronectin type-III 28 DOMAIN 3846 3932 Fibronectin type-III 29 DOMAIN 3933 4023 Fibronectin type-III 30 DOMAIN 4019 4234 Fibrinogen C-terminal
EGF-like sequence regions
156 - 168 CEPGWGGPTCSDP 183 - 213 GSCPDDCNDQGRCVRGRCVCFPGYTGPSCGW 214 - 244 PSCPGDCQGRGRCVQGVCVCRAGFSGPDCSQ 245 - 275 RSCPRGCSQRGRCEGGRCVCDPGYTGDDCGM 276 - 306 RSCPRGCSQRGRCENGRCVCNPGYTGEDCGV 307 - 337 RSCPRGCSQRGRCKDGRCVCDPGYTGEDCGT 338 - 368 RSCPWDCGEGGRCVDGRCVCWPGYTGEDCST 369 - 399 RTCPRDCRGRGRCEDGECICDTGYSGDDCGV 400 - 430 RSCPGDCNQRGRCEDGRCVCWPGYTGTDCGS 431 - 461 RACPRDCRGRGRCENGVCVCNAGYSGEDCGV 462 - 492 RSCPGDCRGRGRCESGRCMCWPGYTGRDCGT 493 - 523 RACPGDCRGRGRCVDGRCVCNPGFTGEDCGS 524 - 554 RRCPGDCRGHGLCEDGVCVCDAGYSGEDCST 555 - 585 RSCPGGCRGRGQCLDGRCVCEDGYSGEDCGV 586 - 616 RQCPNDCSQHGVCQDGVCICWEGYVSEDCSI 617 - 647 RTCPSNCHGRGRCEEGRCLCDPGYTGPTCAT 648 - 679 RMCPADCRGRGRCVQGVCLCHVGYGGEDCGQE 684 - 714 SACPGGCGPRELCRAGQCVCVEGFRGPDCAI 715 - 746 QTCPGDCRGRGECHDGSCVCKDGYAGEDCGEE
Function
Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors
Motifs
MOTIF 1666 1668 Cell attachment site
Disease
"DISEASE: Ehlers-Danlos syndrome, classic-like (EDSCLL) [MIM:606408]: A form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility EDSCLL patients lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos syndrome Delayed wound healing is only present in a subset of patients EDSCLL inheritance is autosomal recessive Note=The disease is caused by mutations affecting the gene represented in this entry ; DISEASE: Vesicoureteral reflux 8 (VUR8) [MIM:615963]: A disease belonging to the group of congenital anomalies of the kidney and urinary tract It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections Primary disease results from a developmental defect of the ureterovesical junction In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease Note=The disease is caused by mutations affecting the gene represented in this entry"