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P24821 Proteins EGF-like domain Repeats
Uniprot ID:P24821
Protein name: Tenascin
Gene : TNC HXB
Protein Family:Tenascin family
Squence Length : 2201
Sequnce
>P24821 2202 MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTEALPLLENLTISDINPYGFTVSWMASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKPLRAEIVTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA
Domains
DOMAIN 174 186 EGF-like 1 incomplete DOMAIN 186 217 EGF-like 2 DOMAIN 217 248 EGF-like 3 DOMAIN 248 280 EGF-like 4 DOMAIN 280 311 EGF-like 5 DOMAIN 311 342 EGF-like 6 DOMAIN 342 373 EGF-like 7 DOMAIN 373 404 EGF-like 8 DOMAIN 404 435 EGF-like 9 DOMAIN 435 466 EGF-like 10 DOMAIN 466 497 EGF-like 11 DOMAIN 497 528 EGF-like 12 DOMAIN 528 559 EGF-like 13 DOMAIN 559 590 EGF-like 14 DOMAIN 590 621 EGF-like 15 DOMAIN 625 715 Fibronectin type-III 1 DOMAIN 716 804 Fibronectin type-III 2 DOMAIN 805 894 Fibronectin type-III 3 DOMAIN 895 990 Fibronectin type-III 4 DOMAIN 991 1075 Fibronectin type-III 5 DOMAIN 1076 1165 Fibronectin type-III 6 DOMAIN 1167 1256 Fibronectin type-III 7 DOMAIN 1258 1350 Fibronectin type-III 8 DOMAIN 1351 1439 Fibronectin type-III 9 DOMAIN 1440 1531 Fibronectin type-III 10 DOMAIN 1533 1621 Fibronectin type-III 11 DOMAIN 1622 1711 Fibronectin type-III 12 DOMAIN 1712 1801 Fibronectin type-III 13 DOMAIN 1802 1888 Fibronectin type-III 14 DOMAIN 1889 1977 Fibronectin type-III 15 DOMAIN 1975 2190 Fibrinogen C-terminal
EGF-like sequence regions
174 - 186 CEPGWKGPNCSEP 186 - 217 PECPGNCHLRGRCIDGQCICDDGFTGEDCSQL 217 - 248 LACPSDCNDQGKCVNGVCICFEGYAGADCSRE 248 - 280 EICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKP 280 - 311 PLCLNNCYNRGRCVENECVCDEGFTGEDCSEL 311 - 342 LICPNDCFDRGRCINGTCYCEEGFTGEDCGKP 342 - 373 PTCPHACHTQGRCEEGQCVCDEGFAGVDCSEK 373 - 404 KRCPADCHNRGRCVDGRCECDDGFTGADCGEL 404 - 435 LKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQL 435 - 466 LRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDM 466 - 497 MSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDR 497 - 528 RQCPRDCSNRGLCVDGQCVCEDGFTGPDCAEL 528 - 559 LSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQ 559 - 590 QRCPSDCHGQGRCVDGQCICHEGFTGLDCGQH 590 - 621 HSCPSDCNNLGQCVSGRCICNEGYSGEDCSEV
Function
"Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327)"
Disease
"DISEASE: Deafness, autosomal dominant, 56 (DFNA56) [MIM:615629]: A form of non-syndromic sensorineural hearing loss Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information DFNA56 is characterized by progressive hearing impairment with post-lingual onset Note=The disease is caused by mutations affecting the gene represented in this entry"