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P25791 Proteins LIM zinc-binding domain Repeats
Uniprot ID:P25791
Protein name: Rhombotin-2
Gene : LMO2 RBTN2 RBTNL1 RHOM2 TTG2
Protein Family:
Squence Length : 158
Sequnce
>P25791 159 MSSAIERKSLDPSEEPVDEVLQIPPSLLTCGGCQQNIGDRYFLKAIDQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRDYLRLFGQDGLCASCDKRIRAYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKINGMI
Domains
DOMAIN 30 89 LIM zinc-binding 1 DOMAIN 94 153 LIM zinc-binding 2
LIM zinc-binding sequence regions
30 - 89 GCQQNIGDRYFLKAIDQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRDYLRLFGQD 94 - 153 SCDKRIRAYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKIN
Function
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state
Disease
"DISEASE: Note=A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL) Translocation t(11,14)(p13;q11) with TCRD"