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P30101 Proteins Thioredoxin domain Repeats

Uniprot ID:P30101	Protein name: Protein disulfide-isomerase A3	Gene : PDIA3 ERP57 ERP60 GRP58
Protein Family:Protein disulfide isomerase family	Squence Length : 505

Sequnce	>P30101 506 MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREATNPPVIQEEKPKKKKKAQEDL
Domains	DOMAIN 25 133 Thioredoxin 1 DOMAIN 343 485 Thioredoxin 2
Thioredoxin sequence regions	25 - 133 VLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPA 343 - 485 DGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREATNP
Active Site	ACT_SITE 57 57 Nucleophile. ACT_SITE 60 60 Nucleophile. ACT_SITE 406 406 Nucleophile. ACT_SITE 409 409 Nucleophile
Motifs	MOTIF 502 505 Prevents secretion from ER
Mutation	57 57 C->A: No loss of activity when associated with A-406 57 57 C->S: Activity changed to serine protease 60 60 C->S: Activity changed to serine protease when associated with S-409 406 406 C->A: No loss of activity when associated with A-57 406 406 C->S: Activity changed to serine protease 409 409 C->S: Activity changed to serine protease when associated with S-60