HOME BACK

P35590 Proteins EGF-like domain Repeats

Uniprot ID:P35590	Protein name: Tyrosine-protein kinase receptor Tie-1	Gene : TIE1 TIE
Protein Family:"Protein kinase superfamily, Tyr protein kinase family, Tie subfamily"	Squence Length : 1138

Sequnce	>P35590 1139 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPPLLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
Domains	DOMAIN 43 105 Ig-like C2-type 1 DOMAIN 214 256 EGF-like 1 DOMAIN 258 303 EGF-like 2 DOMAIN 305 345 EGF-like 3 DOMAIN 372 426 Ig-like C2-type 2 DOMAIN 446 545 Fibronectin type-III 1 DOMAIN 548 642 Fibronectin type-III 2 DOMAIN 646 739 Fibronectin type-III 3 DOMAIN 839 1118 Protein kinase
EGF-like sequence regions	214 - 256 GAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQA 258 - 303 REGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEA 305 - 345 APGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKS
Function	Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis
Active Site	ACT_SITE 979 979 Proton acceptor
Binding Site	BINDING 870 870 ATP
Nucleotide Binding	NP_BIND 845 853 ATP