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P42566 Proteins UIM domain Repeats
Uniprot ID:P42566
Protein name: Epidermal growth factor receptor substrate 15
Gene : EPS15 AF1P
Protein Family:
Squence Length : 896
Sequnce
>P42566 897 MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA
Domains
DOMAIN 15 104 EH 1 DOMAIN 128 216 EH 2 DOMAIN 160 195 EF-hand 1 DOMAIN 223 258 EF-hand 2 DOMAIN 224 314 EH 3 DOMAIN 851 870 UIM 1 DOMAIN 877 896 UIM 2
UIM sequence regions
851 - 870 EDMIEWAKRESEREEEQRLA 877 - 896 QEDLELAIALSKSEISEA
Function
"Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2"
Motifs
MOTIF 768 774 SH3-binding
Calcium Binding
CA_BIND 173 184 1. CA_BIND 236 247 2
Mutation
154 154 V->E: Loss of interaction with STON2 NPF motifs 169 169 W->A: Loss of interaction with STON2 NPF motifs
Disease
DISEASE: Note=A chromosomal aberration involving EPS15 is found in acute leukemias Translocation t(1;11)(p32;q23) with KMT2A/MLL1 The result is a rogue activator protein