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P48059 Proteins LIM zinc-binding domain Repeats
Uniprot ID:P48059
Protein name: LIM and senescent cell antigen-like-containing domain protein 1
Gene : LIMS1 PINCH PINCH1
Protein Family:
Squence Length : 325
Sequnce
>P48059 326 MANALASATCERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVIEGDVVSALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVCKKCYEKFPLELKKRLKKLAETLGRK
Domains
DOMAIN 10 62 LIM zinc-binding 1 DOMAIN 71 121 LIM zinc-binding 2 DOMAIN 135 184 LIM zinc-binding 3 DOMAIN 193 243 LIM zinc-binding 4 DOMAIN 252 303 LIM zinc-binding 5
LIM zinc-binding sequence regions
10 - 62 RCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQ 71 - 121 QCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHN 135 - 184 KCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELKGELYCLPCHD 193 - 243 ACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYN 252 - 303 HCNRVIEGDVVSALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVCKKCYE
Function
"Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation"
Mutation
42 42 F->A: Loss of interaction with ILK and loss of localization to focal adhesion 56 56 R->A: Alters interaction with ILK 61 61 H->D: Alters interaction with ILK 62 62 D->A: Alters interaction with ILK 66 66 L->D: Alters interaction with ILK