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P51797 Proteins CBS domain Repeats

Uniprot ID:P51797	Protein name: Chloride transport protein 6	Gene : CLCN6 KIAA0046
Protein Family:"Chloride channel (TC 2.A.49) family, ClC-6/CLCN6 subfamily"	Squence Length : 869

Sequnce	>P51797 870 MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVEKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRSQSMKSYPSSELRNMCDEHIASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFLQARLRQHYQTI
Domains	DOMAIN 605 662 CBS 1 DOMAIN 807 868 CBS 2
CBS sequence regions	605 - 662 PNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSI 807 - 868 PSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFLQARLRQHYQTI
Function	"Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter"
Motifs	MOTIF 156 160 Selectivity filter part_1. MOTIF 198 202 Selectivity filter part_2. MOTIF 487 491 Selectivity filter part_3
Binding Site	BINDING 157 157 Chloride. BINDING 489 489 Chloride. via amide nitrogen. BINDING 576 576 Chloride
Nucleotide Binding	NP_BIND 630 632 ATP. NP_BIND 849 852 ATP
Mutation	410 410 N->A: Abolishes N-glycosylation when associated with A-422 and A-432 422 422 N->A: Abolishes N-glycosylation when associated with A-410 and A-432 432 432 N->A: Abolishes N-glycosylation when associated with A-410 and A-422