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P53671 Proteins LIM zinc-binding domain Repeats

Uniprot ID:P53671	Protein name: LIM domain kinase 2	Gene : LIMK2
Protein Family:"Protein kinase superfamily, TKL Ser/Thr protein kinase family"	Squence Length : 638

Sequnce	>P53671 639 MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
Domains	DOMAIN 12 63 LIM zinc-binding 1 DOMAIN 72 124 LIM zinc-binding 2 DOMAIN 152 239 PDZ DOMAIN 331 608 Protein kinase
LIM zinc-binding sequence regions	12 - 63 GCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYW 72 - 124 GCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHN
Function	Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro
Active Site	ACT_SITE 451 451
Binding Site	BINDING 360 360 ATP
Nucleotide Binding	NP_BIND 337 345 ATP
Mutation	505 505 T->E: Increases kinase activity 505 505 T->V: Abolishes cofilin phosphorylation and enhancement of stress fiber formation